研究室の業績
原著論文
Sakakibara M, Uenoyama Y, Minabe S, Watanabe Y, Deura C, Nakamura S, Suzuki G, Maeda K-I and Tsukamura H. (2013) Microarray Analysis of Perinatal-Estrogen-Induced Changes in Gene Expression Related to Brain Sexual Differentiation in Mice. PLoS ONE 8(11): e79437 (doi:10.1371/journal.pone.0079437).
Naniwa Y, Nakatsukasa K, Setsuda S, Oishi S, Fujii N, Matsuda F, Uenoyama Y, Tsukamura H, Maeda KI, Ohkura S. (2013) Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows. J Reprod Dev (http://dx.doi.org/10.1262/jrd.2013-064).
Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda KI, Tsukamura H. (2013) Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats. J Reprod Dev 59: 479-484 (http://dx.doi.org/10.1262/jrd.2013-046).
Suetomi Y, Matsuda F, Uenoyama Y, Maeda KI, Tsukamura H, Ohkura S. (2013) Molecular cloning and identification of the transcriptional regulatory domain of the goat neurokinin B Gene TAC3. J Reprod Dev 59: 463-469 (http://dx.doi.org/10.1262/jrd.2013-037).
Mostari MP, Ieda N, Deura C, Minabe S, Yamada S, Uenoyama Y, Maeda KI, Tsukamura H. (2013) Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. J Reprod Dev 59, 266-272 (http://dx.doi.org/10.1262/jrd.2012-193).
Sakakibara M, Deura C, Minabe S, Iwata Y, Uenoyama Y, Maeda KI, Tsukamura H. (2013) Different critical perinatal periods and hypothalamic sites of oestradiol action in the defeminization of LH surge and lordosis capacity in the rat. J Neuroendocrinol 25:251-259.
Yamada S, Uenoyama Y, Deura C, Minabe S, Naniwa Y, Iwata K, Kawata M, Maeda KI, Tsukamura H. (2012) Oestrogen-dependent suppression of pulsatile luteinizing hormone secretion and Kiss1 mRNA expression in the arcuate nucleus during late lactation in rats. J Neuroendocrinol 24:1234-1242 (doi: 10.1111/j.1365-2826.2012.02330.x.).
Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda KI, Tsukamura H (2012) Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1114245109
Shimizu Y, Tomikawa J, Hirano K, Nanikawa Y, Akazome Y, Kanda S, Kazeto Y, Okuzawa K, Uenoyama Y, Ohkura S, Tsukamura H, Maeda KI, Gen K, Oka Y, Yamamoto N (2012) Central distribution of kiss2 neurons and peri-pubertal changes in their expression in the brain of male and female red seabream Pagrus major. Gen Comp Endocrinol 175:432-442.
Tomikawa, J., Shimokawa, H., Uesaka, M., Yamamoto, N., Mori, Y., Tsukamura, H., Maeda, K.-I. and Imamura, T. (2011) Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines. J. Biol. Chem. 286, 34788-34799.
Matsuyama, S., Ohkura, S., Mogi, K., Wakabayashi, Y., Mori, Y., Tsukamura, H., Maeda, K.-I., Ichikawa, M. and Okamura, H. (2011). Morphological evidence for direct interaction between kisspeptin and GnRH neurons at the median eminence of the male goat: an immunoelectron microscopic study. Neuroendocrinology, 94, 323-332.
Inoue N, Sasagawa K, Ikai K, Sasaki Y, Tomikawa J, Oishi S, Fujii N, Uenoyama Y, Ohmori Y, Yamamoto N, Hondo E, Maeda K and Tsukamura H (2011) Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus). Proc Natl Acad Sci U S A 108:17527-32.
Iwata K, Kinoshita M, Susaki N, Uenoyama Y, Tsukamura H and Maeda KI (2011) Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats. J Reprod Dev 57:379-384.
Iwata K, Kinoshita M, Yamada S, Imamura T, Uenoyama Y, Tsukamura H and Maeda KI (2011) Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats. J Physiol Sci 61:103-113.
Minabe S, Uenoyama Y, Tsukamura H and Maeda KI (2011) Analysis of pulsatile and surge-like luteinizing hormone secretion with frequent blood sampling in female mice. J Reprod Dev 57:660-664.
Noritake KI, Matsuoka T, Ohsawa T, Shimomura K, Sanbuissho A, Uenoyama Y, Maeda KI and Tsukamura H (2011) Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats. J Reprod Dev 57:409-415.
Noritake KI, Suzuki J, Matsuoka T, Makino T, Ohnishi H, Shimomura K, Uenoyama Y, Tsukamura H, Maeda KI and Sanbuissho A (2011) Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs. Reprod Toxicol 31:440-446.
Uenoyama Y, Inoue N, Pheng V, Homma T, Takase K, Yamada S, Ajiki K, Ichikawa M, Okamura H, Maeda KI and Tsukamura H (2011) Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone interaction in the median eminence of female rats: Implication of axo-axonal regulation of GnRH release. J Neuroendocrinol 23:863-870.
Oishi S, Misu R, Tomita K, Setsuda S, Masuda R, Ohno H, Naniwa Y, Ieda N, Inoue N, Ohkura S, Uenoyama Y, Tsukamura H, Maeda K-I, Hirasawa A, Tsujimoto G and Fujii N (2010) Activation of neuropeptide FF receptor by kisspeptin receptor ligands ACS Med Chem Lett 2: 53-57.
Tsukamura H, Homma T, Tomikawa J, Uenoyama Y and Maeda K (2010) Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats. Ann N Y Acad Sci 1200: 95-103.
Tomikawa J, Homma T, Tajima S, Shibata T, Inamoto Y, Takase K, Inoue N, Ohkura S, Uenoyama Y, Maeda KI and Tsukamura H (2010) Molecular Characterization and Estrogen Regulation of Hypothalamic KISS1 Gene in the Pig. Biol Reprod 82: 313-319.
Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA and Okamura H (2010) Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci 30: 3124-32.
Homma T, Sakakibara M, Yamada S, Kinoshita M, Iwata K, Tomikawa J, Kanazawa T, Matsui H, Takatsu Y, Ohtaki T, Matsumoto H, Uenoyama Y, Maeda KI and Tsukamura H (2009) Significance of Neonatal Testicular Sex Steroids to Defeminize Anteroventral Periventricular Kisspeptin Neurons and the GnRH/LH Surge System in Male Rats. Biol Reprod 81: 1216-1225.
Matsuyama S, Ohkura S, Iwata K, Uenoyama Y, Tsukamura H, Maeda KI and Kimura K (2009) Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat. J Reprod Dev 55: 256-261.
Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda KI and Okamura H (2009) Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. J Neuroendocrinol 21: 813-21.
Pheng V, Uenoyama Y, Homma T, Inamoto Y, Takase K, Yoshizawa-Kumagaye K, Isaka S, Watanabe TX, Ohkura S, Tomikawa J, Maeda K and Tsukamura H (2009) Potencies of centrally- or peripherally-injected full-length kisspeptin or its C-terminal decapeptide on LH release in intact male rats. J Reprod Dev 55: 378-82.
Takase K, Uenoyama Y, Inoue N, Matsui H, Yamada S, Shimizu M, Homma T, Tomikawa J, Kanda S, Matsumoto H, Oka Y, Tsukamura H and Maeda KI (2009) Possible role of oestrogen in pubertal increase of Kiss1/kisspeptin expression indiscrete hypothalamic areas of female rats. J Neuroendocrinol, 21: 527-37.
Uenoyama Y, Tsukamura H and Maeda KI (2009) Kisspeptin/metastin: A key molecule controlling two modes of gonadotrophin-releasing hormone/luteinising hormone release in female rats. J Neuroendocrinol 21: 299-304.
Kanda S, Akazome Y, Matsunaga T, Yamamoto N, Yamada S, Tsukamura H, Maeda K and Oka Y (2008) Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (oryzias latipes). Endocrinology 149: 2467-76.
Sajapitak S, Iwata K, Shahab M, Uenoyama Y, Yamada S, Kinoshita M, Bari FY, I'Anson H, Tsukamura H and Maeda K (2008) Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats. Endocrinology 149: 3016-24.
Sajapitak S, Uenoyama Y, Yamada S, Kinoshita M, Iwata K, Bari FY, I'Anson H, Tsukamula H and Maeda KI (2008) Paraventricular alpha1- and alpha2-adrenergic receptors mediate hindbrain lipoprivation-induced suppression of luteinizing hormone pulses in female rats. J Reprod Dev 54: 198-202.
Uenoyama Y, Tsukamura H, Kinoshita M, Yamada S, Iwata K, Pheng V, Sajapitak S, Sakakibara M, Ohtaki T, Matsumoto H and Maeda KI (2008) Oestrogen-dependent stimulation of luteinising hormone release by galanin-like peptide in female rats. J Neuroendocrinol 20: 626-31.
Adachi S, Yamada S, Takatsu Y, Matsui H, Kinoshita M, Takase K, Sugiura H, Ohtaki T, Matsumoto H, Uenoyama Y, Tsukamura H, Inoue K and Maeda K (2007) Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. J Reprod Dev 53: 367-78.
Yamada S, Uenoyama Y, Kinoshita M, Iwata K, Takase K, Matsui H, Adachi S, Inoue K, Maeda KI and Tsukamura H (2007) Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats. Endocrinology 148: 2226-32.
Shahab M, Sajapitak S, Tsukamura H, Kinoshita M, Matsuyama S, Ohkura S, Yamada S, Uenoyama Y, I'Anson H and Maeda K (2006) Acute lipoprivation suppresses pulsatile luteinizing hormone secretion without affecting food intake in female rats. J Reprod Dev 52: 763-72.
Reyes, B.A.S., Tsukamura, H., I’Anson, H., Estacio, M.A.C., Hirunagi, K. and Maeda, K.-I. (2006) Temporal expression of estrogen receptor α in the hypothalamus and medulla oblongata during fasting: a role of noradrenergic neurons. Journal of Endocrinology 190:593-600.
Reyes BA, Bautista ND, Tanquilut NC, Anunciado RV, Leung AB, Sanchez GC, Magtoto RL, Castronuevo P, Tsukamura H, Maeda KI (2006) Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats. J Ethnopharmacol 105:196-20.
Yamada S, Uenoyama Y, Maeda K and Tsukamura H (2006) Role of noradrenergic receptors in the bed nucleus of the stria terminalis in regulating pulsatile luteinizing hormone secretion in female rats. J Reprod Dev 52: 115-21.
Kinoshita M, Tsukamura H, Adachi S, Matsui H, Uenoyama Y, Iwata K, Yamada S, Inoue K, Ohtaki T, Matsumoto H and Maeda K (2005) Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. Endocrinology 146: 4431-6.
Matsuyama, S., Ohkura, S., Sakurai, K., Tsukamura, H., Maeda, K.-I. and Okamura, H. (2005) Activation of melanocortin receptors accelerates the gonadotropin-releasing hormone pulse generator activity in goats. Neuroscience Letters, 383, 289-294.
著書・総説
Okamura H, Tsukamura H, Ohkura S, Uenoyama Y, Wakabayashi Y, Maeda KI. (2013) Kisspeptin and GnRH Pulse Generation. Adv Exp Med Biol. 2013;784:297-323. doi: 10.1007/978-1-4614-6199-9_14.
井上直子・束村博子・前多敬一郎 (2012) キスペプチンと生殖腺刺激ホルモン放出ホルモン(GnRH)分泌. 臨床神経科学 30, 220-222.
前多敬一郎・束村博子・上野山賀久 (2012) ストレスが繁殖に与える影響〜内分泌学的影響と知見〜 臨床獣医 1, 12-15.
井上直子・上野山賀久・大蔵聡・束村博子・前多敬一郎 (2011) 卵胞発育と成熟(1) 卵胞発育の中枢制御機構. Hormone Frontier in Gynecology 18, 391-394.
上野山賀久・大蔵聡・井上直子・前多敬一郎・束村博子 (2011) 特集 生理活性ペプチド・機能性ペプチド−研究の最先端−キスペプチンによる繁殖機能制御機構. 臨床化学 40, 113-118.
大蔵聡・上野山賀久・冨川順子・井上直子・束村博子・前多敬一郎 (2010) キスペプチン/メタスチン−繁殖を制御する新規神経ペプチド. 日本産業動物獣医師会雑誌 64, 39-44.
Maeda K, Ohkura S, Uenoyama Y, Wakabayashi Y, Oka Y, Tsukamura H and Okamura H (2010) Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus. Brain Res 1364: 103-15.
前多敬一郎・束村博子（2009）バイオテクノロジーと家畜、ヒトと動物の関係学、第2巻「家畜の文化」秋篠宮文仁・林良博編、岩波書店 218-237.
Ohkura S, Uenoyama Y, Yamada S, Homma T, Takase K, Inoue N, Maeda KI and Tsukamura H (2009) Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats. Peptides 30: 49-56.
Uenoyama Y, Tsukamura H and Maeda KI (2009) Kisspeptin/metastin: A key molecule controlling two modes of gonadotrophin-releasing hormone/luteinising hormone release in female rats. J Neuroendocrinol 21: 299-304.
束村博子・前多敬一郎（2008）生殖を司る神経ペプチド、メタスチン（キスペプチン）成長発達 15, 1-4.
束村博子・上野山賀久・山田俊児・冨川順子・大蔵聡・井上直子・前多敬一郎（2008）視床下部−下垂体−性腺軸のマスターレギュレーターとしてのメタスチン（キスペプチン）ホルモンと臨床 56, 771-777.
束村博子・上野山賀久・大蔵聡・前多敬一郎（2008）メタスチン／キスペプチン−種を超えて生殖を司る神経ペプチド 化学と生物 46, 234-236.
前多敬一郎・束村博子・上野山賀久・大蔵聡（2007）メタスチン（キスペプチン）：新しい繁殖制御の可能性を秘めた神経ペプチド．臨床獣医 25, 62-65.
上野山賀久・束村博子・前多敬一郎（2007）中枢内分泌の最新知見とその異常．２．メタスチン．産科と婦人科 74, 898-903.
前多敬一郎・束村博子（2007）生理的GnRH放出因子，メタスチン（キスペプチン）の基礎と応用．家畜診療 54, 589-594.
前多敬一郎・上野山賀久・大蔵聡・束村博子（2007）繁殖メカニズムの中枢ペプチド、メタスチン（キスペプチン）をめぐる新しい性腺刺激剤の可能性（その１）．家畜人工授精 241, 22-36.
前多敬一郎・上野山賀久・大蔵聡・束村博子（2007）繁殖メカニズムの中枢ペプチド、メタスチン（キスペプチン）をめぐる新しい性腺刺激剤の可能性（その２）．家畜人工授精 242, 7-24.
前多敬一郎・束村博子（2007）メタスチン（キスペプチン）：生殖機能を制御する神経ペプチド、ホルモンと臨床 55, 147-154.
Maeda K,Adachi, S., Inoue, K., Ohkura, S. and Tsukamura H. (2007) Metastin/Kisspeptin and control of estrous cycle in rats. Reviews in Endocrine and Metabolic Disorders 8: 21-29.
岩田衣世・束村博子・前多敬一郎 (2007) 繁殖機能を制御するエネルギーセンサーとその応用の可能性、獣医畜産新報 60, 455-460.
前多敬一郎・束村博子（2006） 脳の性分化 山内兄人・新井康允編、裳華房 199-208.
Maeda K, Tsukamura H. (2006) The impact of stress on reproduction: are glucocorticoids inhibitory or protective to gonadotropin secretion? Endocrinology 147:1085-6.
束村博子・木下美香・足立幸香・井上金治・前多敬一郎 (2006) メタスチン：生殖機能を制御する中心的ペプチド、内分泌・糖尿病科 22: 416-420.
大蔵聡・木下美香・上野山賀久・束村博子・前多敬一郎（2006）生殖機能の神経内分泌メカニズム、２１世紀の動物科学、第１０巻「内分泌現象と生命活動」、日本動物学会編、培風館 40-76.
