動物生殖科学研究室の業績

原著論文  著書・総説

new Deura C, Minabe S, Ikegami K, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H. (2018) Morphological analysis for neuronal pathway from the hindbrain ependymocytes to the hypothalamic kisspeptin neurons. J Reprod Dev, in press.

new Sugimoto A, Tsuchida H, Ieda N, Ikegami K, Inoue N, Uenoyama Y, Tsukamura H. (2018) Somatostatin-somatostatin receptor 2 signaling mediates LH pulse suppression in lactating rats. Endocrinology, in press.

new Assadullah, Ieda N, Bayer DM, Stanikzai PM, Memlawal R, Inoue N, Uenoyama Y, Tsukamura H. (2018) Study on the Reproductive Performance and Problems in Crossbred Cows in Jalalabad, East of Afghanistan. J Intl Cooper Agric Dev, in press.

new Assadullah, Ieda N, Kawai N, Ishii H, Ihara K, Inoue N, Uenoyama Y, Tsukamura H. (2018) Co-expression of the calcitonin receptor gene in the hypothalamic kisspeptin neurons in female rats. Reprod Med Biol, doi.org/10.1002/rmb2.12085

Nakajo M, Kanda S, Karigo T, Takahashi A, Akazome Y, Uenoyama Y, Kobayashi M, Oka Y. (2017) Evolutionally conserved function of kisspeptin neuronal system is non-reproductive regulation as revealed by nonmammalian study. Endocrinology, 159:163-183 (doi: 10.1210/en.2017-00808).

Bun C, Watanabe Y, Uenoyama Y, Inoue N, Ieda N, Matsuda F, Tsukamura H, Kuwahara M, Maeda KI, Ohkura S, Pheng V (2017) Evaluation of heat stress response in crossbred dairy cows under tropical climate by analysis of heart rate variability. J Vet Med Sci, in press.

Nakamura S, Ito Y, Yamamoto K, Takahashi C, Dai M, Tanahashi M, Uenoyama Y, Tsukamura H, Oishi S, Maeda K-I, Matsuda F. (2017) SB223412, a neurokinin-3 receptor-selective antagonist, suppresses testosterone secretion in male guinea pigs. Theriogenology 102, 183-189.

Watanabe Y, Ikegami K, Ishigaki R, Ieda N, Uenoyama Y, Maeda KI, Tsukamura H, Inoue N. (2017) Enhancement of the LH surge by male olfactory signals is associated with AVPV Kiss1 cell activation in female rats. J Neuroendocrinol, doi: 10.1111/jne.12505.

Ikegami K, Minabe S, Ieda N, Goto T, Sugimoto A, Nakamura S, Inoue N, Oishi S, Maturana AD, Sanbo M, Hirabayashi M, Maeda KI, Tsukamura H, Uenoyama Y (2017) Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones. J Neuroendocrinol, doi: 10.1111/jne.12480.

Minabe S, Ieda N, Watanabe Y, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H. (2017) Long-term neonatal estrogen exposure causes irreversible inhibition of LH pulses by suppressing arcuate kisspeptin expression via estrogen receptors alpha and beta in female rodents. Endocrinology 158:2918-2929 (doi: 10.1210/en.2016-1144).

Ieda N, Watanabe Y, Bun C, Pheng V, Uenoyama Y. (2017) Characterization of smallholder livestock farming in Kampong Cham province, Cambodia -A pilot study in Prey Chhor district-. J Intl Cooper Agric Dev 15: 42-47.

Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A. (2017) CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. Sci Rep. 7:42476.

Nakamura S, Uenoyama Y, Ikegami K, Dai M, Watanabe Y, Takahashi C, Hirabayashi M, Tsukamura H, Maeda KI. (2016) Neonatal kisspeptin is steroid-independently required for defeminisation and peripubertal kisspeptin-induced testosterone is required for masculinisation of the brain: A behavioural study using Kiss1 KO rats. J Neuroendocrinol (doi: 10.1111/jne.12409).

Hassaneen ASA, Naniwa Y, Suetomi Y, Matsuyama S, Kimura K, Ieda N, Inoue N, Uenoyama Y, Tsukamura H, Maeda K-I, Matsuda F, Ohkura S. (2016) Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers. J Reprod Dev 62: 471-477 (doi: 10.1262/jrd.2016-075).

Uenoyama Y, Tanaka A, Takase K, Yamada S, Pheng V, Inoue N, Maeda KI, Tsukamura H. (2015) Central estrogen action sites involved in prepubertal restraint of pulsatile luteinizing hormone release in female rats. J Reprod Dev 61: 351-359 (doi: 10.1262/jrd.2014-143).

Minabe S, Deura C, Ikegami K, Goto T, Sanbo M, Hirabayashi M, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H (2015) Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents. Endocrinology 156: 2278-2287 (doi: 10.1210/en.2014-2018).

Uenoyama Y, Nakamura S, Hayakawa Y, Ikegami K, Watanabe Y, Deura C, Minabe S, Tomikawa J, Goto T, Ieda N, Inoue N, Sanbo M, Tamura C, Hirabayashi M, Maeda KI, Tsukamura H. (2015) Lack of pulse and surge modes and glutamatergic stimulation of LH release in Kiss1 knockout rats. J Neuroendocrinol 27:187-197 (doi: 10.1111/jne.12257).

Matsuda F, Nakatsukasa K, Suetomi Y, Naniwa Y, Ito D, Inoue N, Wakabayashi Y, Okamura H, Maeda KI, Uenoyama Y, Tsukamura H, Ohkura S. (2015) The LH surge-generating system is functional in male goats as in females: involvement of kisspeptin neurones in the medial preoptic area. J Neuroendocrinol 27:57–65 (doi: 10.1111/jne.12235).

Goto T, Tomikawa J, Ikegami K, Minabe S, Abe H, Fukanuma T, Imamura T, Takase K, Sanbo M, Tomita K, Hirabayashi M, Maeda KI, Tsukamura H, Uenoyama Y. (2015) Identification of hypothalamic arcuate nucleus-specific enhancer region of Kiss1 gene in mice. Mol Endocrinol 29:121-129 (doi: 10.1210/me.2014-1289).

Watanabe Y, Uenoyama Y, Suzuki J, Takase K, Suetomi Y, Ohkura S, Inoue N, Maeda KI, Tsukamura H. (2014) Oestrogen-induced activation of preoptic kisspeptin neurones may be involved in the luteinizing hormone surge in male and female Japanese monkeys. J Neuroendocrinol 26: 909-917 (doi: 10.1111/jne.12227).

Ieda N, Uenoyama Y, Tajima Y, Nakata T, Kano M, Naniwa Y, Watanabe Y, Minabe S, Tomikawa J, Inoue N, Matsuda F, Ohkura S, Maeda KI, Tsukamura H. (2014) KISS1 gene expression in the developing brain of female pigs in pre- and peripubertal periods. J Reprod Dev 60 (4):312-316 (doi.org/10.1262/jrd.2013-129).

Kaneda M, Misu R, Ohno H, Hirasawa A, Ieda N, Uenoyama Y, Tsukamura H, Maeda KI, Oishi S, Fujii N. (2014) Design and synthesis of fluorescent probes for GPR54. Bioorg Med Chem 22: 3325-3330 (doi:10.1016/j.bmc.2014.04.052).

中田智子・田島瑶子・野口倫子・上野山賀久・大蔵聡・前多敬一郎・鈴木千恵・吉岡耕治 (2014) プロスタグランジンF2α及び性腺刺激ホルモンによる排卵同期化法を用いた豚の定時人工授精. 日獣会誌 2014;67:119-124.

Sakakibara M, Uenoyama Y, Minabe S, Watanabe Y, Deura C, Nakamura S, Suzuki G, Maeda KI and Tsukamura H. (2013) Microarray analysis of perinatal-estrogen-induced changes in gene expression related to brain sexual differentiation in mice. PLoS ONE 8(11): e79437 (doi:10.1371/journal.pone.0079437).

Naniwa Y, Nakatsukasa K, Setsuda S, Oishi S, Fujii N, Matsuda F, Uenoyama Y, Tsukamura H, Maeda KI, Ohkura S. (2013) Effects of full-length kisspeptin administration on follicular development in japanese black beef cows. J Reprod Dev 59: 588-594(http://dx.doi.org/10.1262/jrd.2013-064).

Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda KI, Tsukamura H. (2013) Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats. J Reprod Dev 59: 479-484 (http://dx.doi.org/10.1262/jrd.2013-046).

Suetomi Y, Matsuda F, Uenoyama Y, Maeda KI, Tsukamura H, Ohkura S. (2013) Molecular cloning and identification of the transcriptional regulatory domain of the goat neurokinin B gene TAC3. J Reprod Dev 59: 463-469 (http://dx.doi.org/10.1262/jrd.2013-037).

Mostari MP, Ieda N, Deura C, Minabe S, Yamada S, Uenoyama Y, Maeda KI, Tsukamura H. (2013) Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. J Reprod Dev 59, 266-272 (http://dx.doi.org/10.1262/jrd.2012-193).

Sakakibara M, Deura C, Minabe S, Iwata Y, Uenoyama Y, Maeda KI, Tsukamura H. (2013) Different critical perinatal periods and hypothalamic sites of oestradiol action in the defeminization of LH surge and lordosis capacity in the rat. J Neuroendocrinol 25:251-259.

Yamada S, Uenoyama Y, Deura C, Minabe S, Naniwa Y, Iwata K, Kawata M, Maeda KI, Tsukamura H. (2012) Oestrogen-dependent suppression of pulsatile luteinizing hormone secretion and Kiss1 mRNA expression in the arcuate nucleus during late lactation in rats. J Neuroendocrinol 24:1234-1242 (doi: 10.1111/j.1365-2826.2012.02330.x.).

Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda KI, Tsukamura H (2012) Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain. Proc Natl Acad Sci U S A. 109(20):E1294-301 (doi:10.1073/pnas.1114245109)

Shimizu Y, Tomikawa J, Hirano K, Nanikawa Y, Akazome Y, Kanda S, Kazeto Y, Okuzawa K, Uenoyama Y, Ohkura S, Tsukamura H, Maeda KI, Gen K, Oka Y, Yamamoto N (2012) Central distribution of kiss2 neurons and peri-pubertal changes in their expression in the brain of male and female red seabream Pagrus major. Gen Comp Endocrinol 175:432-442.

Tomikawa, J., Shimokawa, H., Uesaka, M., Yamamoto, N., Mori, Y., Tsukamura, H., Maeda, K.-I. and Imamura, T. (2011) Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines. J. Biol. Chem. 286, 34788-34799.

Matsuyama, S., Ohkura, S., Mogi, K., Wakabayashi, Y., Mori, Y., Tsukamura, H., Maeda, K.-I., Ichikawa, M. and Okamura, H. (2011). Morphological evidence for direct interaction between kisspeptin and GnRH neurons at the median eminence of the male goat: an immunoelectron microscopic study. Neuroendocrinology 94, 323-332.

Inoue N, Sasagawa K, Ikai K, Sasaki Y, Tomikawa J, Oishi S, Fujii N, Uenoyama Y, Ohmori Y, Yamamoto N, Hondo E, Maeda K and Tsukamura H (2011) Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus). Proc Natl Acad Sci U S A 108:17527-32.

Iwata K, Kinoshita M, Susaki N, Uenoyama Y, Tsukamura H and Maeda KI (2011) Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats. J Reprod Dev 57:379-384.

Iwata K, Kinoshita M, Yamada S, Imamura T, Uenoyama Y, Tsukamura H and Maeda KI (2011) Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats. J Physiol Sci 61:103-113.

Minabe S, Uenoyama Y, Tsukamura H and Maeda KI (2011) Analysis of pulsatile and surge-like luteinizing hormone secretion with frequent blood sampling in female mice. J Reprod Dev 57:660-664.

Noritake KI, Matsuoka T, Ohsawa T, Shimomura K, Sanbuissho A, Uenoyama Y, Maeda KI and Tsukamura H (2011) Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats. J Reprod Dev 57:409-415.

Noritake KI, Suzuki J, Matsuoka T, Makino T, Ohnishi H, Shimomura K, Uenoyama Y, Tsukamura H, Maeda KI and Sanbuissho A (2011) Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs. Reprod Toxicol 31:440-446.

Uenoyama Y, Inoue N, Pheng V, Homma T, Takase K, Yamada S, Ajiki K, Ichikawa M, Okamura H, Maeda KI and Tsukamura H (2011) Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone interaction in the median eminence of female rats: Implication of axo-axonal regulation of GnRH release. J Neuroendocrinol 23:863-870.

Oishi S, Misu R, Tomita K, Setsuda S, Masuda R, Ohno H, Naniwa Y, Ieda N, Inoue N, Ohkura S, Uenoyama Y, Tsukamura H, Maeda K-I, Hirasawa A, Tsujimoto G and Fujii N (2010) Activation of neuropeptide FF receptor by kisspeptin receptor ligands ACS Med Chem Lett 2: 53-57.

Tsukamura H, Homma T, Tomikawa J, Uenoyama Y and Maeda K (2010) Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats. Ann N Y Acad Sci 1200: 95-103.

Tomikawa J, Homma T, Tajima S, Shibata T, Inamoto Y, Takase K, Inoue N, Ohkura S, Uenoyama Y, Maeda KI and Tsukamura H (2010) Molecular Characterization and Estrogen Regulation of Hypothalamic KISS1 Gene in the Pig. Biol Reprod 82: 313-319.

Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA and Okamura H (2010) Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci 30: 3124-32.

Homma T, Sakakibara M, Yamada S, Kinoshita M, Iwata K, Tomikawa J, Kanazawa T, Matsui H, Takatsu Y, Ohtaki T, Matsumoto H, Uenoyama Y, Maeda KI and Tsukamura H (2009) Significance of Neonatal Testicular Sex Steroids to Defeminize Anteroventral Periventricular Kisspeptin Neurons and the GnRH/LH Surge System in Male Rats. Biol Reprod 81: 1216-1225.

Matsuyama S, Ohkura S, Iwata K, Uenoyama Y, Tsukamura H, Maeda KI and Kimura K (2009) Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat. J Reprod Dev 55: 256-261.

Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda KI and Okamura H (2009) Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. J Neuroendocrinol 21: 813-21.

Pheng V, Uenoyama Y, Homma T, Inamoto Y, Takase K, Yoshizawa-Kumagaye K, Isaka S, Watanabe TX, Ohkura S, Tomikawa J, Maeda K and Tsukamura H (2009) Potencies of centrally- or peripherally-injected full-length kisspeptin or its C-terminal decapeptide on LH release in intact male rats. J Reprod Dev 55: 378-82.

Takase K, Uenoyama Y, Inoue N, Matsui H, Yamada S, Shimizu M, Homma T, Tomikawa J, Kanda S, Matsumoto H, Oka Y, Tsukamura H and Maeda KI (2009) Possible role of oestrogen in pubertal increase of Kiss1/kisspeptin expression indiscrete hypothalamic areas of female rats. J Neuroendocrinol, 21: 527-37.

Uenoyama Y, Tsukamura H and Maeda KI (2009) Kisspeptin/metastin: A key molecule controlling two modes of gonadotrophin-releasing hormone/luteinising hormone release in female rats. J Neuroendocrinol 21: 299-304.

Kanda S, Akazome Y, Matsunaga T, Yamamoto N, Yamada S, Tsukamura H, Maeda K and Oka Y (2008) Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (oryzias latipes). Endocrinology 149: 2467-76.

Sajapitak S, Iwata K, Shahab M, Uenoyama Y, Yamada S, Kinoshita M, Bari FY, I'Anson H, Tsukamura H and Maeda K (2008) Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats. Endocrinology 149: 3016-24.

Sajapitak S, Uenoyama Y, Yamada S, Kinoshita M, Iwata K, Bari FY, I'Anson H, Tsukamula H and Maeda KI (2008) Paraventricular alpha1- and alpha2-adrenergic receptors mediate hindbrain lipoprivation-induced suppression of luteinizing hormone pulses in female rats. J Reprod Dev 54: 198-202.

Uenoyama Y, Tsukamura H, Kinoshita M, Yamada S, Iwata K, Pheng V, Sajapitak S, Sakakibara M, Ohtaki T, Matsumoto H and Maeda KI (2008) Oestrogen-dependent stimulation of luteinising hormone release by galanin-like peptide in female rats. J Neuroendocrinol 20: 626-31.

Adachi S, Yamada S, Takatsu Y, Matsui H, Kinoshita M, Takase K, Sugiura H, Ohtaki T, Matsumoto H, Uenoyama Y, Tsukamura H, Inoue K and Maeda K (2007) Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. J Reprod Dev 53: 367-78.

Yamada S, Uenoyama Y, Kinoshita M, Iwata K, Takase K, Matsui H, Adachi S, Inoue K, Maeda KI and Tsukamura H (2007) Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats. Endocrinology 148: 2226-32.

Shahab M, Sajapitak S, Tsukamura H, Kinoshita M, Matsuyama S, Ohkura S, Yamada S, Uenoyama Y, I'Anson H and Maeda K (2006) Acute lipoprivation suppresses pulsatile luteinizing hormone secretion without affecting food intake in female rats. J Reprod Dev 52: 763-72.

Reyes, B.A.S., Tsukamura, H., I’Anson, H., Estacio, M.A.C., Hirunagi, K. and Maeda, K.-I. (2006) Temporal expression of estrogen receptor α in the hypothalamus and medulla oblongata during fasting: a role of noradrenergic neurons. Journal of Endocrinology 190:593-600.

Reyes BA, Bautista ND, Tanquilut NC, Anunciado RV, Leung AB, Sanchez GC, Magtoto RL, Castronuevo P, Tsukamura H, Maeda KI (2006) Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats. J Ethnopharmacol 105:196-20.

Yamada S, Uenoyama Y, Maeda K and Tsukamura H (2006) Role of noradrenergic receptors in the bed nucleus of the stria terminalis in regulating pulsatile luteinizing hormone secretion in female rats. J Reprod Dev 52: 115-21.

Kinoshita M, Tsukamura H, Adachi S, Matsui H, Uenoyama Y, Iwata K, Yamada S, Inoue K, Ohtaki T, Matsumoto H and Maeda K (2005) Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. Endocrinology 146: 4431-6.

Matsuyama, S., Ohkura, S., Sakurai, K., Tsukamura, H., Maeda, K.-I. and Okamura, H. (2005) Activation of melanocortin receptors accelerates the gonadotropin-releasing hormone pulse generator activity in goats. Neuroscience Letters, 383, 289-294.

apple.png