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Yamada K, Mano T, Hazim S, Takizawa M, Inoue N, Uenoyama Y, Tsukamura H (2024) Neonatal aromatase inhibition blocked defeminization of AVPV Kiss1 neurons and LH surge-generating system in male rats. Endocrinologys, bqae028 (PMID: 38470466)
Ozaki R, Inoue S, Yorozui Y, Ichikawa R, Yamada N, Higashi S, Matsuyama S, Tsukamura H, Ohkura S, Uenoyama Y, Morita Y (2023) Capturing temperature changes on the ocular surface along with estrus and ovulation using infrared thermography in Japanese Black cows. J Reprod Dev, 70: 49-54. (PMID: 38008463)Nagae M, Yamada K, Enomoto Y, Kometani M, Tsuchida H, Panthee A, Nonogaki M, Matsunaga N, Takizawa M, Matsuzaki S, Hirabayashi M, Inoue N, Tsukamura H, Uenoyama Y (2023) Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats. Sci Rep 13: 20495. (PMID: 37993510)
See also news release in the Eurekalert!
Yamada K, Nagae M, Mano T, Tsuchida H, Hazim S, Goto T, Sanbo M, Hirabayashi M, Inoue N, Uenoyama Y, Tsukamura H (2023) Sex difference in developmental changes in visualized Kiss1 neurons in newly generated Kiss1-Cre rats. J Reprod Dev 69(5):227-238. (PMID: 37518187)
Uenoyama Y, Tsukamura H. (2023) KNDy neurones and GnRH/LH pulse generation: Current understanding and future aspects. J Neuroendocrinol : e13285. (PMID: 37232103)
Uenoyama Y, Inoue N, Tsukamura H. (2023) Kisspeptin and lactational anestrus: Current understanding and future prospects. Peptides : 171026. (PMID: 37230188)
Inoue N, Hazim S, Tsuchida H, Dohi Y, Ishigaki R, Takahashi A, Otsuka Y, Yamada K, Uenoyama Y, Tsukamura H. (2023) Hindbrain adenosine 5-triphosphate (ATP)-purinergic signaling triggers LH surge and ovulation via activation of AVPV kisspeptin neurons in rats. J Neurosci 43 (12): 2140-2152. (PMID: 36813577)
See also About the Cover image for the J Neurosci 43(12)
See also news release in the Eurekalert!
Tsuchida H, Nonogaki M, Takizawa M, Inoue N, Uenoyama Y, Tsukamura H. (2023) Enkephalin-delta opioid receptor signaling mediates glucoprivic suppression of LH pulse and gluconeogenesis in female rats. Endocrinology 164 (3): bqac216. (PMID: 36592113)
Shima Y, Miyabayashi K, Mori T, Ono K, Kajimoto M, Cho HL, Tsuchida H, Uenoyama Y, Tsukamura H, Suzuki K, Choi MH, Toida K. (2022) Intronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model. Int J Mol Sci 24: 192. (PMID: 36613635)
Tsuchida H, Nonogaki M, Inoue N, Uenoyama Y, Tsukamura H. (2022) Dynorphin-kappa-opioid receptor signaling, but not mu-opioid receptor signaling, partly mediates the suppression of luteinizing hormone release during late lactation in rats. Neurosci Lett 791: 136920. (PMID: 36272558)
Inoue N, Hotta A, Goto T, Hirabayashi M, Uenoyama Y, Tsukamura H. (2022) Establishment of embryo transfer in the musk shrew (Suncus murinus). J Reprod Dev 68: 340-344. (PMID: 36070889)
Uenoyama Y, Tsuchida H, Nagae M, Inoue N, Tsukamura H. (2022) Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals. Front Neurosci 16: 958377. (PMID: 36033602)
Sugimoto A, Tsuchida H, Nagae M, Inoue N, Uenoyama Y, Tsukamura H. (2022) Central somatostatin-somatostatin receptor 2 signaling mediates lactational suppression of luteinizing hormone release via the inhibition of glutamatergic interneurons during late lactation in rats. J Reprod Dev 68(3): 190-197. (PMID: 35249910)
Oikawa M, Nagae M, Mizuno N, Iwatsuki K, Yoshida F, Inoue N, Uenoyama Y, Tsukamura H, Nakauchi H, Hirabayashi M, Kobayashi T. (2022) Generation of Tfap2c-T2A-tdTomato knock-in reporter rats via adeno-associated virus-mediated efficient gene targeting. Mol Reprod Dev 89(3):129-132. (PMID: 35170139)
Chen J, Minabe S, Munetomo A, Magata F, Sato M, Nakamura S, Hirabayashi M, Ishihara Y, Yamazaki T, Uenoyama Y, Tsukamura H, Matsuda F. (2022) Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats. Endocr J 69(7): 797-807. (PMID: 35125377)
Ikegami K, Watanabe Y, Nakamura S, Goto T, Inoue N, Uenoyama Y, Tsukamura H. (2022) Cellular and molecular mechanisms regulating the KNDy neuronal activities to generate and modulate GnRH pulse in mammals. Front Neuroendocrinol. 64:100968. (PMID: 34808231)
Nakamura S, Watanabe Y, Goto T, Ikegami K, Inoue N, Uenoyama Y, Tsukamura H. (2022) Kisspeptin neurons as a key player bridging the endocrine system and sexual behavior in mammals. Front Neuroendocrinol 64: 100952. (PMID: 34755641)
Uenoyama Y, Nagae M, Tsuchida H, Inoue N, Tsukamura H. (2021) Role of KNDy neurons expressing kisspeptin, neurokinin B, and dynorphin A as a GnRH pulse generator controlling mammalian reproduction. Front Endocrinol (Lausanne) 12: 724632. (PMID: 34566891)
Uenoyama Y, Inoue N, Nakamura S, Tsukamura H. (2021) Kisspeptin neurons and estrogen-estrogen receptor α signaling: Unraveling the mystery of steroid feedback system regulating mammalian reproduction. Int J Mol Sci 22: 9229. (PMID: 34502135)
Sato M, Minabe S, Sakono T, Magata F, Nakamura S, Watanabe Y, Inoue N, Uenoyama Y, Tsukamura H, Matsuda F. (2021) Morphological Analysis of the Hindbrain Glucose Sensor-Hypothalamic Neural Pathway Activated by Hindbrain Glucoprivation. Endocrinology 162: bqab125. (PMID: 34161572)
Oshimo Y, Munetomo A, Magata F, Suetomi Y, Sonoda S, Takeuchi Y, Tsukamura H, Ohkura S, Matsuda F. (2021) Estrogen increases KISS1 expression in newly generated immortalized KISS1-expressing cell line derived from goat preoptic area. J Reprod Dev 67: 15-23. (PMID: 33100283)
Tsuchida H, Kawai N, Yamada K, Takizawa M, Inoue N, Uenoyama Y, Tsukamura H. (2021) Central μ-opioid receptor antagonism blocks glucoprivic LH pulse suppression and gluconeogenesis/feeding in female rats. Endocrinology 162: bqab140. (PMID: 34270714)
Dai M, Nakamura S, Takahashi C, Sato M, Munetomo A, Magata F, Uenoyama Y, Tsukamura H, Matsuda F. (2021) Reduction of arcuate kappa-opioid receptor-expressing cells increased luteinizing hormone pulse frequency in female rats. Endoc J 68(8): 933-941. (PMID: 33867395)
Minabe S, Iwata K, Tsuchida H, Tsukamura H, Ozawa H. (2021) Effect of diet-induced obesity on kisspeptin-neurokinin B-dynorphin A neurons in the arcuate nucleus and luteinizing hormone secretion in sex hormone-primed male and female rats. Peptides 142: 170546. (PMID: 33794282)
Tsukamura H. (2021) Kobayashi Award 2019: The neuroendocrine regulation of the mammalian reproduction. Gen Comp Endocrinol 2021: 113755. (PMID: 33711315)
Nagae M, Uenoyama Y, Okamoto S, Tsuchida H, Ikegami K, Goto T, Majarune S, Nakamura S, Sanbo M, Hirabayashi M, Kobayashi K, Inoue N, Tsukamura H. (2021) Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator. Proc Natl Acad Sci USA 118: e2009156118. (PMID: 33500349)
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Watanabe Y, Ikegami K, Nakamura S, Uenoyama Y, Ozawa H, Maeda KI, Tsukamura H, Inoue N. (2020) Mating-induced increase in Kiss1 mRNA expression in the anteroventral periventricular nucleus prior to an increase in LH and testosterone release in male rats. J Reprod Dev 66(6): 579-586. (PMID: 32968033)
Tsuchida H, Mostari P, Yamada K, Miyazaki S, Enomoto Y, Inoue N, Uenoyama Y, Tsukamura H. (2020) Paraventricular dynorphin A neurons mediate LH pulse suppression induced by hindbrain glucoprivation in female rats. Endocrinology 161:bqaa161. (PMID: 32894768)
Goto T, Hirabayashi M, Watanabe Y, Sanbo M, Tomita K, Inoue N, Tsukamura H, Uenoyama Y. (2020) Testosterone supplementation rescues spermatogenesis and in vitro fertilizing ability of sperm in Kiss1 knockout mice. Endocrinology 161:bqaa092. (PMID: 32514526)
See also a commentary on this article.
Morita Y, Ozaki R, Mukaiyama A, Sasaki T, Tatebayashi R, Morishima A, Kitagawa Y, Suzumura R, Abe R, Tsukamura H, Matsuyama S, Ohkura S. (2020) Establishment of long-term chronic recording technique of in vivo ovarian parenchymal temperature in Japanese Black cows. J Reprod Dev 2020. J. Reprod. Dev. 66(3):271-275.. (PMID: 32062640)
Suetomi Y, Tatebayashi R, Sonoda S, Munetomo A, Matsuyama S, Inoue N, Uenoyama Y, Takeuchi Y, Tsukamura H, Ohkura S, Matsuda F. (2020) Establishment of immortalised cell lines derived from female Shiba goat KNDy and GnRH neurones. J Neuroendocrinol 32:e12857. (PMID: 32432378)
Ikegami K, Goto T, Nakamura S, Watanabe Y, Sugimoto A, Majarune S, Horihata K, Nagae M, Tomikawa J, Imamura T, Sanbo M, Hirabayashi M, Inoue N, Maeda KI, Tsukamura H, Uenoyama Y. (2020) Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice. J Reprod Dev 66:359-367. (PMID: 32307336)
Minabe S, Nakamura S, Fukushima E, Sato M, Ikegami K, Goto T, Sanbo M, Hirabayashi M, Tomikawa J, Imamura T, Inoue N, Uenoyama Y, Tsukamura H, Maeda KI, Matsuda F. (2020) Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice. J Reprod Dev 66:369-375. (PMID: 32336702)
Sasaki T, Sonoda T, Tatebayashi R, Kitagawa Y, Oishi S, Yamamoto K, Fujii N, Inoue N, Uenoyama Y, Tsukamura H, Maeda KI, Matsuda F, Morita Y, Matsuyama S, Ohkura S. (2020) Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats. J Reprod Dev 66(4):351-357. (PMID: 32281549)
Tep B, Morita Y, Matsuyama S, Ohkura S, Inoue N, Tsukamura H, Uenoyama Y and Pheng V. (2020) Seasonal changes in the reproductive performance in local cows receiving artificial insemination in the Pursat province of Cambodia. Asian Australas J Anim Sci, 33(12): 1922-1929. (PMID: 32299175)
Horihata K, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H. (2020) Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents. J Reprod Dev 66(2):125-133. (PMID: 31956172)
Matsuda F, Ohkura S, Magata F, Munetomo A, Chen J, Sato M, Inoue N, Uenoyama Y, Tsukamura H. (2019) Role of kisspeptin neurons as a GnRH surge generator: Comparative aspects in rodents and non-rodent mammals. J Obstet Gynaecol Res, 45(12):2318-2329. (PMID: 31608564)
Ieda N, Hassaneen ASA, Inoue N, Uenoyama Y, Tsukamura H. (2019) Kisspeptin: A Central Regulator of Reproduction in Mammals. SVU- International Journal of Veterinary Sciences 3(1): 10-26.
Uenoyama Y, Inoue N, Nakamura S, Tsukamura H. (2019) Central mechanism controlling pubertal onset in mammals: a triggering role of kisspeptin. Front Endocrinol (Lausanne) 10:312. (PMID: 31164866)
Majarune S, Pelden Nima, Sugimoto A, Nagae M, Inoue N, Tsukamura H, Uenoyama Y. (2019) Ad libitum feeding triggers puberty onset associated with increases in arcuate Kiss1 and Pdyn expression in growth-retarded rats. J Reprod Dev 65(5): 397-406. (PMID: 31155522)
Minabe S, Sato M, Inoue N, Watanabe Y, Magata F, Matsuda F, Uenoyama Y, Ozawa H, Tsukamura H. (2019) Neonatal estrogen causes irreversible male infertility via specific suppressive action on hypothalamic Kiss1 neurons. Endocrinology 160(5): 1223-1233. (PMID: 30920587)
See also Eureka 2019: Rodent Studies Unlock Endocrine Secrets
Sasaki T, Ito D, Sonoda T, Morita Y, Wakabayashi Y, Yamamura T, Okamura H, Oishi S, Noguchi T, Fujii N, Uenoyama Y, Tsukamura H, Maeda KI, Matsuda F, Ohkura S. (2019) Peripheral administration of κ-opioid receptor antagonist stimulates gonadotropin-releasing hormone pulse generator activity in ovariectomized, estrogen-treated female goats. Domest Anim Endocrinol 68:83-91. (PMID: 30908995)
Deura C, Minabe S, Ikegami K, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H. (2019) Morphological analysis for neuronal pathway from the hindbrain ependymocytes to the hypothalamic kisspeptin neurons. J Reprod Dev 65(2): 129-137 (PMID: 30662010)
Sugimoto A, Tsuchida H, Ieda N, Ikegami K, Inoue N, Uenoyama Y, Tsukamura H. (2019) Somatostatin-somatostatin receptor 2 signaling mediates LH pulse suppression in lactating rats. Endocrinology 160(2): 473-483. (PMID: 30544226).
Uenoyama Y, Inoue N, Maeda KI, Tsukamura H. (2018) The roles of kisspeptin in the mechanism underlying reproductive functions in mammals. J Reprod Dev 64: 469-476. (PMID: 30298825)
Tsukamura H, Maeda KI, Uenoyama Y. (2018) Fetal/perinatal programming causing sexual dimorphism of the kisspeptin–GnRH neuronal network. In: Herbison AE, Plant TM, eds. The GnRH Neuron and its Control: Wiley, 43-60.
Nakajo M, Kanda S, Karigo T, Takahashi A, Akazome Y, Uenoyama Y, Kobayashi M, Oka Y. (2017) Evolutionally conserved function of kisspeptin neuronal system is non-reproductive regulation as revealed by nonmammalian study. Endocrinology, 159:163-183. (PMID: 29053844)
Bun C, Watanabe Y, Uenoyama Y, Inoue N, Ieda N, Matsuda F, Tsukamura H, Kuwahara M, Maeda KI, Ohkura S, Pheng V (2017) Evaluation of heat stress response in crossbred dairy cows under tropical climate by analysis of heart rate variability. J Vet Med Sci 80:181-185. (PMID: 29225303)
Nakamura S, Ito Y, Yamamoto K, Takahashi C, Dai M, Tanahashi M, Uenoyama Y, Tsukamura H, Oishi S, Maeda KI, Matsuda F. (2017) SB223412, a neurokinin-3 receptor-selective antagonist, suppresses testosterone secretion in male guinea pigs. Theriogenology 102, 183-189. (PMID: 28800500)
Watanabe Y, Ikegami K, Ishigaki R, Ieda N, Uenoyama Y, Maeda KI, Tsukamura H, Inoue N. (2017) Enhancement of the LH surge by male olfactory signals is associated with AVPV Kiss1 cell activation in female rats. J Neuroendocrinol, 29:e12503. (PMID: 28699305)
Ikegami K, Minabe S, Ieda N, Goto T, Sugimoto A, Nakamura S, Inoue N, Oishi S, Maturana AD, Sanbo M, Hirabayashi M, Maeda KI, Tsukamura H, Uenoyama Y (2017) Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones. J Neuroendocrinol 29(6) 1-14. (PMID: 28475285)
Minabe S, Ieda N, Watanabe Y, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H. (2017) Long-term neonatal estrogen exposure causes irreversible inhibition of LH pulses by suppressing arcuate kisspeptin expression via estrogen receptors alpha and beta in female rodents. Endocrinology 158:2918-2929. (PMID: 28368450)
Ieda N, Watanabe Y, Bun C, Pheng V, Uenoyama Y. (2017) Characterization of smallholder livestock farming in Kampong Cham province, Cambodia -A pilot study in Prey Chhor district-. J Intl Cooper Agric Dev 15: 42-47.
Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A. (2017) CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. Sci Rep. 7:42476. (PMID: 28195201)
Uenoyama Y, Pheng V, Tsukamura H, Maeda KI. (2016) The roles of kisspeptin revisited: inside and outside the hypothalamus. J Reprod Dev 62:537-545. (PMID: 27478063)
Uenoyama Y, Inoue N, Ieda N, Pheng V, Maeda KI, Tsukamura H. (2016) Maturation and physiology of hypothalamic regulation of the gonadal axis. In: Kumanov P, Agarwal A eds. Puberty: Physiology and Abnormalities: Springer 1-11
Nakamura S, Uenoyama Y, Ikegami K, Dai M, Watanabe Y, Takahashi C, Hirabayashi M, Tsukamura H, Maeda KI. (2016) Neonatal kisspeptin is steroid-independently required for defeminisation and peripubertal kisspeptin-induced testosterone is required for masculinisation of the brain: A behavioural study using Kiss1 KO rats. J Neuroendocrinol 28(10) 10.1111/jne.12409. (PMID: 27344056)
Hassaneen ASA, Naniwa Y, Suetomi Y, Matsuyama S, Kimura K, Ieda N, Inoue N, Uenoyama Y, Tsukamura H, Maeda KI, Matsuda F, Ohkura S. (2016) Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers. J Reprod Dev 62:471-477. (PMID: 27349533)
Uenoyama Y, Tomikawa J, Inoue N, Goto T, Minabe S, Ieda N, Nakamura S, Watanabe Y, Ikegami K, Matsuda F, Ohkura S, Maeda KI, Tsukamura H. (2016) Molecular and epigenetic mechanism regulating hypothalamic Kiss1 gene expression in mammals. Neuroendocrinology 103: 640-9. (PMID: 26964105)
Uenoyama Y, Tanaka A, Takase K, Yamada S, Pheng V, Inoue N, Maeda KI, Tsukamura H. (2015) Central estrogen action sites involved in prepubertal restraint of pulsatile luteinizing hormone release in female rats. J Reprod Dev 61: 351-359. (PMID: 26004302)
Minabe S, Deura C, Ikegami K, Goto T, Sanbo M, Hirabayashi M, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H (2015) Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents. Endocrinology 156: 2278-2287. (PMID: 25822714)
Uenoyama Y, Nakamura S, Hayakawa Y, Ikegami K, Watanabe Y, Deura C, Minabe S, Tomikawa J, Goto T, Ieda N, Inoue N, Sanbo M, Tamura C, Hirabayashi M, Maeda KI, Tsukamura H. (2015) Lack of pulse and surge modes and glutamatergic stimulation of LH release in Kiss1 knockout rats. J Neuroendocrinol 27:187-197. (PMID: 25582792)
Recomended in Faculty Opinions
Matsuda F, Nakatsukasa K, Suetomi Y, Naniwa Y, Ito D, Inoue N, Wakabayashi Y, Okamura H, Maeda KI, Uenoyama Y, Tsukamura H, Ohkura S. (2015) The LH surge-generating system is functional in male goats as in females: involvement of kisspeptin neurones in the medial preoptic area. J Neuroendocrinol 27:57–65. (PMID: 25367275)
Goto T, Tomikawa J, Ikegami K, Minabe S, Abe H, Fukanuma T, Imamura T, Takase K, Sanbo M, Tomita K, Hirabayashi M, Maeda KI, Tsukamura H, Uenoyama Y. (2015) Identification of hypothalamic arcuate nucleus-specific enhancer region of Kiss1 gene in mice. Mol Endocrinol 29:121-129. (PMID: 25486239)
Watanabe Y, Uenoyama Y, Suzuki J, Takase K, Suetomi Y, Ohkura S, Inoue N, Maeda KI, Tsukamura H. (2014) Oestrogen-induced activation of preoptic kisspeptin neurones may be involved in the luteinizing hormone surge in male and female Japanese monkeys. J Neuroendocrinol 26: 909-917. (PMID: 25283748)
Ieda N, Uenoyama Y, Tajima Y, Nakata T, Kano M, Naniwa Y, Watanabe Y, Minabe S, Tomikawa J, Inoue N, Matsuda F, Ohkura S, Maeda KI, Tsukamura H. (2014) KISS1 gene expression in the developing brain of female pigs in pre- and peripubertal periods. J Reprod Dev 60 (4):312-316. (PMID: 24909600)
Uenoyama Y, Tsukamura H, Maeda KI. (2014) KNDy neuron as a gatekeeper of puberty onset. J Obstet Gynaecol Res 40: 1518-1526. (PMID: 24888910)
Kaneda M, Misu R, Ohno H, Hirasawa A, Ieda N, Uenoyama Y, Tsukamura H, Maeda KI, Oishi S, Fujii N.(2014) Design and synthesis of fluorescent probes for GPR54. Bioorg Med Chem 22: 3325-3330. (PMID: 24857775)
Okamura H, Tsukamura H, Ohkura S, Uenoyama Y, Wakabayashi Y, Maeda KI. (2013) Kisspeptin and GnRH pulse generation. In: Kauffman A., Smith J. (eds) Kisspeptin Signaling in Reproductive Biology. Adv Exp Med Biol. 784:297-323. Springer, New York, NY. (PMID: 23550012)
Sakakibara M, Uenoyama Y, Minabe S, Watanabe Y, Deura C, Nakamura S, Suzuki G, Maeda KI and Tsukamura H. (2013) Microarray analysis of perinatal-estrogen-induced changes in gene expression related to brain sexual differentiation in mice. PLoS ONE 8(11): e79437. (PMID: 24223949)
Naniwa Y, Nakatsukasa K, Setsuda S, Oishi S, Fujii N, Matsuda F, Uenoyama Y, Tsukamura H, Maeda KI, Ohkura S. (2013) Effects of full-length kisspeptin administration on follicular development in japanese black beef cows. J Reprod Dev 59: 588-594. (PMID: 24107742)
Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda KI, Tsukamura H. (2013) Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats. J Reprod Dev 59: 479-484. (PMID: 23877505)
Recomended in Faculty Opinions
Suetomi Y, Matsuda F, Uenoyama Y, Maeda KI, Tsukamura H, Ohkura S. (2013) Molecular cloning and identification of the transcriptional regulatory domain of the goat neurokinin B gene TAC3. J Reprod Dev 59: 463-469. (PMID: 23812498).
Mostari MP, Ieda N, Deura C, Minabe S, Yamada S, Uenoyama Y, Maeda KI, Tsukamura H. (2013) Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. J Reprod Dev 59: 266–272. (PMID: 23391862)
Sakakibara M, Deura C, Minabe S, Iwata Y, Uenoyama Y, Maeda KI, Tsukamura H. (2013) Different critical perinatal periods and hypothalamic sites of oestradiol action in the defeminization of LH surge and lordosis capacity in the rat. J Neuroendocrinol 25:251-259. (PMID: 22994299)
Yamada S, Uenoyama Y, Deura C, Minabe S, Naniwa Y, Iwata K, Kawata M, Maeda KI, Tsukamura H. (2012) Oestrogen-dependent suppression of pulsatile luteinizing hormone secretion and Kiss1 mRNA expression in the arcuate nucleus during late lactation in rats. J Neuroendocrinol 24:1234-1242. (PMID: 22536815)
Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda KI, Tsukamura H (2012) Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain. Proc Natl Acad Sci U S A. 109(20):E1294-301. (PMID: 22505735)
Shimizu Y, Tomikawa J, Hirano K, Nanikawa Y, Akazome Y, Kanda S, Kazeto Y, Okuzawa K, Uenoyama Y, Ohkura S, Tsukamura H, Maeda KI, Gen K, Oka Y, Yamamoto N (2012) Central distribution of kiss2 neurons and peri-pubertal changes in their expression in the brain of male and female red seabream Pagrus major. Gen Comp Endocrinol 175:432-442. (PMID: 22166815)
Tomikawa J, Shimokawa H, Uesaka M, Yamamoto N, Mori Y, Tsukamura H, Maeda KI, Imamura T. (2011) Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines. J. Biol. Chem. 286, 34788-34799. (PMID: 21844201)
Matsuyama S, Ohkura S, Mogi K, Wakabayashi Y, Mori Y, Tsukamura H, Maeda KI, Ichikawa M, Okamura H. (2011) Morphological evidence for direct interaction between kisspeptin and GnRH neurons at the median eminence of the male goat: an immunoelectron microscopic study. Neuroendocrinology, 94, 323-332. (PMID: 22116451)
Inoue N, Sasagawa K, Ikai K, Sasaki Y, Tomikawa J, Oishi S, Fujii N, Uenoyama Y, Ohmori Y, Yamamoto N, Hondo E, Maeda KI, Tsukamura H. (2011) Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus). Proc Natl Acad Sci U S A 108:17527-17532. (PMID: 21987818)
Recomended in Faculty Opinions
Iwata K, Kinoshita M, Susaki N, Uenoyama Y, Tsukamura H, Maeda KI. (2011) Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats. J Reprod Dev 57:379-384. (PMID: 21358145)
JRD Outstanding Paper Award in 2011
Iwata K, Kinoshita M, Yamada S, Imamura T, Uenoyama Y, Tsukamura H, Maeda KI. (2011) Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats. J Physiol Sci 61:103-113. (PMID: 21234734)
2011 Hiroshi and Aya Irisawa Memorial JPS Award
Minabe S, Uenoyama Y, Tsukamura H, Maeda KI. (2011) Analysis of pulsatile and surge-like luteinizing hormone secretion with frequent blood sampling in female mice. J Reprod Dev 57:660-664. (PMID: 21804302)
Noritake KI, Matsuoka T, Ohsawa T, Shimomura K, Sanbuissho A, Uenoyama Y, Maeda KI, Tsukamura H. (2011) Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats. J Reprod Dev 57:409-415. (PMID: 21358144)
Noritake KI, Suzuki J, Matsuoka T, Makino T, Ohnishi H, Shimomura K, Uenoyama Y, Tsukamura H, Maeda KI, Sanbuissho A. (2011) Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs. Reprod Toxicol 31:440-446. (PMID: 21185367)
Uenoyama Y, Inoue N, Pheng V, Homma T, Takase K, Yamada S, Ajiki K, Ichikawa M, Okamura H, Maeda KI, Tsukamura H. (2011) Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone interaction in the median eminence of female rats: Implication of axo-axonal regulation of GnRH release. J Neuroendocrinol 23:863-870. (PMID: 21815953)
Oishi S, Misu R, Tomita K, Setsuda S, Masuda R, Ohno H, Naniwa Y, Ieda N, Inoue N, Ohkura S, Uenoyama Y, Tsukamura H, Maeda KI, Hirasawa A, Tsujimoto G, Fujii N. (2010) Activation of neuropeptide FF receptor by kisspeptin receptor ligands. ACS Med Chem Lett 2: 53-57. (PMID: 24900254)
Maeda KI, Ohkura S, Uenoyama Y, Wakabayashi Y, Oka Y, Tsukamura H, Okamura H. (2010) Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus. Brain Res 1364: 103-15. (PMID: 20951683)
Tsukamura H, Homma T, Tomikawa J, Uenoyama Y, Maeda KI. (2010) Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats. Ann N Y Acad Sci 1200: 95-103. (PMID: 20633137)
Tomikawa J, Homma T, Tajima S, Shibata T, Inamoto Y, Takase K, Inoue N, Ohkura S, Uenoyama Y, Maeda KI, Tsukamura H. (2010) Molecular Characterization and Estrogen Regulation of Hypothalamic KISS1 Gene in the Pig. Biol Reprod 82: 313-319. (PMID: 19828777)
Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA, Okamura H. (2010) Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci 30: 3124-32. (PMID: 20181609)
Recomended in Faculty Opinions
Homma T, Sakakibara M, Yamada S, Kinoshita M, Iwata K, Tomikawa J, Kanazawa T, Matsui H, Takatsu Y, Ohtaki T, Matsumoto H, Uenoyama Y, Maeda KI, Tsukamura H. (2009) Significance of Neonatal Testicular Sex Steroids to Defeminize Anteroventral Periventricular Kisspeptin Neurons and the GnRH/LH Surge System in Male Rats. Biol Reprod 81: 1216-1225. (PMID: 19684332)
Matsuyama S, Ohkura S, Iwata K, Uenoyama Y, Tsukamura H, Maeda KI, Kimura K. (2009) Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat. J Reprod Dev 55: 256-261. (PMID: 19262019)
Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda KI, Okamura H. (2009) Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. J Neuroendocrinol 21: 813-21. (PMID: 19678868)
Recomended in Faculty Opinions
Pheng V, Uenoyama Y, Homma T, Inamoto Y, Takase K, Yoshizawa-Kumagaye K, Isaka S, Watanabe TX, Ohkura S, Tomikawa J, Maeda K, Tsukamura H. (2009) Potencies of centrally- or peripherally-injected full-length kisspeptin or its C-terminal decapeptide on LH release in intact male rats. J Reprod Dev 55: 378-82. (PMID: 19384054)
JRD Outstanding Paper Award in 2009
Takase K, Uenoyama Y, Inoue N, Matsui H, Yamada S, Shimizu M, Homma T, Tomikawa J, Kanda S, Matsumoto H, Oka Y, Tsukamura H, Maeda KI. (2009) Possible role of oestrogen in pubertal increase of Kiss1/kisspeptin expression indiscrete hypothalamic areas of female rats. J Neuroendocrinol, 21: 527-37. (PMID: 19500223)
Uenoyama Y, Tsukamura H, Maeda KI. (2009) Kisspeptin/metastin: A key molecule controlling two modes of gonadotrophin-releasing hormone/luteinising hormone release in female rats. J Neuroendocrinol 21: 299-304. (PMID: 19210293)
Ohkura S, Uenoyama Y, Yamada S, Homma T, Takase K, Inoue N, Maeda KI, Tsukamura H. (2009) Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats. Peptides 30: 49-56. (PMID: 18775461)
Kanda S, Akazome Y, Matsunaga T, Yamamoto N, Yamada S, Tsukamura H, Maeda KI, Oka Y. (2008) Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (oryzias latipes). Endocrinology 149: 2467-76. (PMID: 18202129)
Sajapitak S, Iwata K, Shahab M, Uenoyama Y, Yamada S, Kinoshita M, Bari FY, I'Anson H, Tsukamura H, Maeda KI. (2008) Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats. Endocrinology 149: 3016-24. (PMID: 18308839)
Sajapitak S, Uenoyama Y, Yamada S, Kinoshita M, Iwata K, Bari FY, I'Anson H, Tsukamula H, Maeda KI. (2008) Paraventricular α1- and α2-adrenergic Receptors Mediate Hindbrain Lipoprivation-induced Suppression of Luteinizing Hormone Pulses in Female Rats. J Reprod Dev 54: 198-202. (PMID: 18344615)
Uenoyama Y, Tsukamura H, Kinoshita M, Yamada S, Iwata K, Pheng V, Sajapitak S, Sakakibara M, Ohtaki T, Matsumoto H, Maeda KI. (2008) Oestrogen-dependent stimulation of luteinising hormone release by galanin-like peptide in female rats. J Neuroendocrinol 20: 626-31. (PMID: 18363811)
Maeda KI, Adachi S, Inoue K, Ohkura S, Tsukamura H. (2007) Metastin/Kisspeptin and control of estrous cycle in rats. Reviews in Endocrine and Metabolic Disorders 8: 21-29. (PMID: 17377846)
Yamada S, Uenoyama Y, Kinoshita M, Iwata K, Takase K, Matsui H, Adachi S, Inoue K, Maeda KI, Tsukamura H. (2007) Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats. Endocrinology 148: 2226-32. (PMID: 17289848)
Adachi S, Yamada S, Takatsu Y, Matsui H, Kinoshita M, Takase K, Sugiura H, Ohtaki T, Matsumoto H, Uenoyama Y, Tsukamura H, Inoue K, Maeda KI. (2007) Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. J Reprod Dev 53: 367-78. (PMID: 17213691)
JRD Outstanding Paper Award in 2007
Kinoshita M, Tsukamura H, Adachi S, Matsui H, Uenoyama Y, Iwata K, Yamada S, Inoue K, Ohtaki T, Matsumoto H, Maeda KI. (2005) Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. Endocrinology 146: 4431-6. (PMID: 15976058)
