Publications 50-95
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95. Nakazaki, A.; Nakane, Y.; Ishikawa, Y.; Nishikawa, T. Synthesis of 1.5-dioxaspiro[3.4]octane through bromocation-induced cascade cyclization. Heterocycles. 2015, 91, 1157. DOI:10.3987/COM-15-13208
94. Nakazaki, A.; Miyagawa, K.; Miyata, N.; Nishikawa, T. Synthesis of a C-N Axially Chiral N-Aryl Isatin through Asymmetric Intramolecular N-Arylation. Eur. J. Org. Chem. 2015, 4603-4606. DOI: 10.1002/ejoc.201500593
93. Nakazaki, A.; Miyagawa, K.; Nishikawa, T. Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from N-Aryl-3-Chlorooxindoles Bearing C–N Axial Chirality via Nucleophilic Substitution. Synlett. 2015, 26, 1116-1120. DOI: 10.1055/s-0034-1380266
92. Adachi, M.; Torii, M.; Nishikawa, T. Stereocontrolled Synthesis of ABC-tricycle of Solanoeclepin A. . Synlett. 2015,965-969. DOI: 10.1055/s-0034-1380399
91. Kimura, R.; Sawayama, Y.; Nakazaki, A.; Miyamoto, K.; Uchiyama, M.; Nishikawa, T. Unexpected Metal-Free Transformation of gem-Dibromomethylenes to Ketones under Acetylation Conditions. Chem. Asian J. 2015, 10, 1035-1041. DOI: 10.1002/asia.201403277
90. Takanashi, T.; Tamura, K.; Suzuki, T.; Nakazaki, A.; Kobayashi, S. Synthetic study of spiroiridal triterpenoids: construction of functionalized spiro[4.5]decane skeleton using Claisen rearrangement of 2-(alkenyl)dihydropyran. Tetrahedron Lett. 2015, 56, 327-330.DOI: 10.1016/j.tetlet.2014.11.078
89. Adachi, M.; Hashimoto, H.; Sakakibara, R.; Imazu, T.; Nishikawa, T. A New Deprotection Procedure of MTM Ether. Synlett 2014, 2498-2502. DOI: 10.1055/s-0034-1379027
88. Adachi, M.; Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T. Synthesis of 5,6,11-Trideoxytetrodotoxin. Chem. Lett. 2014, 43, 1719-1721. DOI: 10.1246/cl.14068
87. Satake, Y.; Adachi, M.; Tokoro, S.; Yotsu-Yamashita, M.; Isobe, M.; Nishikawa, T. Synthesis of 5- and 8-Deoxytetrodotoxin. Chem. Asian. J. 2014, 9, 1922-1932. DOI: 10.1002/asia.201402202
86. Adachi, M.; Imazu, T.; Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T. Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog. Chem. Eur. J. 2014, 20, 1247-1251. DOI: 10.1002/chem.201304110
85. Nakazaki, A.; Ishikawa, Y.; Sawayama, Y.; Yotsu-Yamashita, M.; Nishikawa, T. Synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channel. Org. Biomol. Chem. 2014, 12, 53-56. DOI: 10.1039/c3ob42017e
84. Nakazaki, A.; Huang, W.-Y.; Koga, K.; Yingyongnarongkul, B.; Boonsombat, J.; Sawayama, Y.; Tsujimoto, T.; Nishikawa, T. Structural Study on a Naturally Occurring Terphenyl Quinone. Biosci. Biotechnol. Biochem. 2013, 77, 1529-1532. DOI: 10.1271/bbb.130199
83. Yamada, H.; Adachi, M.; Isobe, M.; Nishikawa, T. Stereocontrolled Synthesis of the Oxathiabicylo[3.3.1]nonane Core Structure of Tagetitoxin. Chem. Commun. 2013, 49, 11221-11223. DOI: 10.1039/C3CC46949B
82. Nishikawa, T.; Isobe, M. Synthesis of Tetrodotoxin, a Classic but Still Fascinating Natural Product. Chem. Rec. 2013, 13, 286-302. DOI: 10.1002/tcr.201200025
81. Yotsu-Yamashita, M.; Abe, Y.; Kudo, Y.; Ritson-Williams, R.; Paul, V. J.; Konoki, K.; Cho, Y.; Adachi, M.; Imazu, T.; Nishikawa, T.; Isobe, M. First Identification of 5,11-Dideoxytetrodotoxin in Marine Animals, and Characterization of Major Fragment Ions of Tetrodotoxin and Its Analogs by High Resolution ESI-MS/MS. Mar. Drugs 2013, 11, 2799-2813. DOI: 10.3390/md11082799
80. Kai, K.; Oba, Y.; Akaike, R.; Murata, A.; Nishikawa, T.; Watanabe, N. Insight into the chemistry of cycloaddition between α-ketol oxylipin and epinephrine: isolation and structure elucidation of a new reaction product. Tetrahedron Lett. 2013, 54, 2247-2250. DOI: 10.1016/j.tetlet.2013.02.062
79. Yamada, H.; Adachi, M.; Isobe, M.; Nishikawa, T. Stereocontrolled Total Synthesis of Polygalolide A. Chem. Asian. J. 2013, 8, 1428-1435. DOI: 10.1002/asia.201300362
78. Nakazaki, A.; Hara, Y.; Kajii, S.; Nishikawa, T. Synthesis of Tetracyclic Indoline and Indolenine Derivatives Having b-Lactam Using Amphiphilic Reactivity of 2-Methylindolenine. Heterocycles 2013, 87, 611-625. DOI: 10.3987/COM-12-12657
77. Adachi, M.; Imazu, T.; Isobe, M.; Nishikawa, T. An Improved Synthesis of (-)-5,11-Dideoxytetrodotoxin. J. Org. Chem. 2013, 78, 1699-1705. DOI: 10.1021/jo302773f
76. Nakazaki, A.; Mori, A.; Kobayashi, S.; Nishikawa, T. Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives. Tetrahedron Lett. 2012, 53, 7131-7134. DOI: 10.1016/j.tetlet.2012.10.092
75. Matsumoto, N.; Tsujimoto, T.; Nakazaki, A.; Isobe, M.; Nishikawa, T. Synthetic Studies on Pactamycin, a Potent Antitumor Antibiotic. RSC Advances, 2012, 2, 9448-9462. DOI: 10.1039/c2ra21060f
Adachi, M.; Higuchi, K.; Thasana, N.; Yamada, H.; Nishikawa, T. Stereocontrolled Synthesis of an Indole Moiety of Sespendole and Stereochemical Assignment of the Side Chain, Org. Lett. 2012, 14, 114-117. DOI: 10.1021/ol202895u
Adachi, M.; Yamada, H.; Isobe, M.; Nishikawa, T. Total Synthesis of Polygalolide A, Org. Lett. 2011, 24, 6532-6535. DOI: 10.1021/ol2028256
Isaji, H.; Nakazaki, A.; Isobe, M.; Nishikawa, T. Concise Synthesis of Deformylflustrabromine, a Marine Indole Alkaloid Through Propargyl Dicobalt Hexacarbonyl Complex, Chem. Lett. 2011, 40, 1079-1081. DOI: 10.1246/cl.2011.1079
Adachi, M.; Komada, T.; Nishikawa, T. A New Ring Expansion for a Chiral Hexahydroazulene Skeleton Possessing an Angular Methyl Group, J. Org. Chem. 2011, 76, 6942-6945.DOI: 10.1021/jo201153h
Sawayama, Y.; Nishikawa, T. A Synthetic Route of the Saxitoxin Skeleton: Synthesis of Decarbamoyl-α-saxitoxinol, an Analog of Saxitoxin Produced by the Cyanobacterium Lyngbya wollei, Angew. Chem. Int. Ed . 2011, 50, 7176-7178. DOI: 10.1002/anie.201102494
Kongjinda, Y. Nakashima, N.Tani, M. Kuse, T. Nishikawa, Chin-Hui Yu, N. Harada, M. Isobe, Dynamic Chirality Determines Critical Roles for Bioluminescence in Symplectin–Dehydrocoelenterazine System, Chem. Asian J., 2011, 6, 2080-2091. DOI: 10.1002/asia.201100089
Sugino, K.; Nakazaki, A.; Isobe, M.; Nishikawa, T. Synthetic Study on Sespendole, an Indole Sesquiterpene Alkaloid: Stereocontrolled Synthesis of the Sesquiterpene Segment Bearing All Requisite Stereogenic Centers. Synlett 2011, 647-650.
Sawayama, Y.; Nishikawa, T. Bromocyclization of Alkynyl Guanidine: A New Approach to the Synthesis of Cyclic Guanidines of Saxitoxin. Synlett 2011, 651-654.
Kuse, M.; Yanagi, M.; Tanaka, E.; Tani, N.; Nishikawa, T. Identification of a Fluorescent Compound in the Cuticle of the Train Millipede Parafontaria laminata armigera. Biosci. Biotechnol. Biochem. 2010, 74, 2307-2309. DOI: 10.1271/bbb.100171
Satake, Y.; Nishikawa, T.; Hiramatsu, T.; Araki, H.; Isobe, M. Scalable Synthesis of a New Dihydroxylated Intermediate for tetrodotoxin and Its Analogues. Synthesis, 1992-1998, 2010.
Nishikawa, T.; Koide, Y.; Adachi, M.; Isobe, M. Synthesis of an Advanced Intermediate Bearing Two Hydroxy Groups for (-)-Tetrodotoxin and Its Analogs. Bull. Chem. Soc. Jpn. 2010, 83, 66-68. DOI: 10.1246/bcsj.20090223
Tanaka, E.; Kuse, M.; Nishikawa, T. Dehydrocoelenterazine Is the Organic Substance Constituting the Prosthetic Group of Pholasin. ChemBioChem, 2009, 10, 2725-2729. DOI: 10.1002/cbic.200900503
Doi, I.; Kuse, M.; Nishikawa, T.; Isobe, M. Selective Oxidation by the Tydroperoxide in the Photoprotein, Aequorin. Bioorg. Med. Chem. 2009, 17, 3399-3404. DOI: 10.1016/j.bmc.2009.03.033
Makarasen, A.; Nishikawa, T.; Isobe, M. Synthesis of Four Lysine-Linked Cereulide Analogs showing K+ Ionophoric Activity as Lead Compounds forEmetic Toxin-Detection by Immunoassays. Synthesis, 2184-2204, 2009.
Makarasen, A.; Kuse, M.; Nishikawa, T.; Isobe, M. Substituent Effect of Imino-O-arenesulfonates, a Coupling Partner in Suzuki–Miyaura Reaction for Substitution of the Pyrazine Ring: A Study for the Synthesis of Coelenterazine Analogs Bull. Chem. Soc. Jpn, 82, 870-878, 2009. DOI: 10.1246/bcsj.82.870
Nishikawa, T.; Urabe, D.; Isobe, M. Syntheses of N-Acylosoxazolidine derivatives, related to a partial strycture found in zetekitoxin AB, a Golden Frog Poison. Heterocyles, 79. 379-385, 2009. DOI: 10.3987/COM-08-S(D)44
Kuse, M.; Tanaka, E.; Nishikawa, T. Pholasin luminescence is enhanced by addition of dehydrocoelenterazine, Bioorganic & Medicinal Chemistry Letters , 18, 5657–5659, 2008. DOI: 10.1016/j.bmcl.2008.08.113
Sugino, K.; Yoshimura, H.; Nishikawa, T.; Isobe, M. Regioselectivity of Larock Indole Synthesis by Using Functionalized Alkynes, Bioscience, Biotechnology & Biochemistry, 2008, 72, 2092-2102. DOI: 10.1271/bbb.80179
Kajii, S. Nishikawa, T.; Isobe, M. Synthetic studies and biosynthetic speculation on marine alkaloid chartelline, Chem. Commun, 3121-3123, 2008. DOI: 10.1039/b803797c
Kajii, S. Nishikawa, T.; Isobe, M. Synthesis of N-Hydroxyenamide by N-Acylation of Oxime Derivative for Synthesis of Chartelline, a Novel Marine Alkaloid, Tetrahedron Letters. 49, 594-597, 2008. DOI: 10.1016/j.tetlet.2007.11.155
Sawayama, Y.; Tsujimoto, T.; Sugino, K.; Nishikawa, T.; Isobe., M.; Kawagishi, H.; Syntheses of Naturally Occurring Terphenyls and Its Related Compounds, Bioscience, Biotechnology & Biochemistry, 70, 2998-3003, 2006. DOI: 10.1271/bbb.60389
Nishikawa, T.; Urabe, D.; Tomita, M.; Tsujimoto, T.; Iwabuchi, T.; Isobe, M. One-Pot Transformation of Trichloroacetamide into Readily Deprotectable Carbamates, Organic Letters, 8, 3263-3265, 2006. DOI: 10.1021/ol061123c
Urabe, D.; Nishikawa, T.; Isobe, M. An Efficient Total Synthesis of Optically Active Tetrodotoxin from Levoglucosenone, Chemistry, An Asian Journal, 1, 125-135, 2006. DOI: 10.1002/asia.200600038
51. Nishikawa, T.; Koide, Y.; Kanakubo, A.; Yoshimura, H.; Isobe, M. Synthesis of β−Analogues of C-Mannosyltryptophan, a Novel C-Glycosylamino Acid Found in Proteins, Organic Biochemical Chemistry, 4, 1268-1277, 2006. DOI: 10.1039/b516282c
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