Publications 1-50
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50.
Tsujimoto, T.; Nishikawa, T.; Urabe, D.; Isobe, M. Synthesis of Functionalized Cyclopentane for Pactamycin, A potent Antitumor Antibiotic, Synlett, 433-436, 2005.
49.
Nishikawa, T.; Koide, Y.; Kajii, S.; Wada, K.; Ishikawa, M., Isobe, M. Stereocontrolled Synthesis of α-C-Mannosyltryptohan and its Analogues. Organic Biochemical Chemistry, 3, 687-700 2005.
48.
Urabe, D.; Sugino K.; Nishikawa, T.; Isobe, M. A novel deprotection of trichloroacetamide, Tetrahedron Letters, 45, 9405-9407. 2004. DOI: 10.1016/j.tetlet.2004.10.099
47.
Nishikawa, T.; Kajii, S.; Isobe, M. Novel Synthesis of Bromoindolenine with Spiro-β-lactam in Chartelline. Synlett, 2025-2027, 2004.
46.
Nishikawa, T.; Urabe, D.; Isobe, M. An efficient total synthesis of optically active tetrodotoxin. Angewante. Chemie International Edition, 43, 4782-4785, 2004 (in English). (2) Nishikawa, T.; Urabe, D.; Isobe, M. An efficient total synthesis of optically active tetrodotoxin, Angewandte Chemie, 116, 4886-4889, 2004 (in German). DOI: 10.1002/ange.200460293
45.
Nishikawa, T.; Kajii, S.; Isobe, M. Synthesis of Model Compound Containing an Indole Spiro-β-lactam Moiety with Vinylchloride in Chartellines. Chemistry Letters, 33, 440-441, 2004. DOI: 10.1246/cl.2004.440
44.
Nishikawa, T.; Kajii, S.; Sato, C.; Yasukawa, Z.; Kitajima, K.; Isobe, M. α-C-Mannnosyltryptophan is not recognized by conventional mannose-binding lectins. Bioorganic Medicinal Chemistry, 12, 2343-2348, 2004. DOI: 10.1016/j.bmc.2004.02.009
43.
Nishikawa, T.; Urabe, D.; Yoshida, K.; Iwabuchi, T.; Asai, M.; Isobe, M. Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analog of Puffer Fish Toxin. Chemistry, A European Journal. 10, 452-462, 2004. DOI: 10.1002/chem.200305111
42.
Nishikawa, T.; Mishima, M.; Ohyabu, N.; Isobe, M. A Novel and Highly Stereoselective Carbon-chain Extension Reaction at the C-6 Position of 1,6-Anhydropyranose, Tetrahedron Letters, 45, 175-178, 2004. DOI: 10.1016/j.tetlet.2003.10.135
41.
Yotsu-Yamashita, M.; Urabe, D.; Asai, M.; Nishikawa, T.; Isobe M. Biological activity of 8,11-dideoxytetrodotoxin: Lethality to mice and the inhibitory activity to cytotoxicity of ouabain and veratridine in mouse neuroblastoma cells, Neuro-2a, Toxicon, 42, 557-560, 2003. DOI: 10.1016/j.toxicon.2003.08.002
40.
Ohyabu, N.; Nishikawa, T.; Isobe, M. The First Asymmetric Total Synthesis of Tetrodotoxin, Journal of American Chemical Society, 125, 8798-8805, 2003. DOI: 10.1021/ja0342998
39.
Nishikawa, T.; Urabe, D.; Yoshida, K.; Iwabuchi, T.; Asai, M.; Isobe, M. Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analog of Puffer Fish Toxin, Organic Letters, 4, 2679-2682 2002. DOI: 10.1021/ol026177a
38.
Nishikawa, T.; Wada, K.; Isobe, M. Synthesis of Novel α-C-Glycosylamino Acids and Reverse Regioselectivity in Larock's Heteroannulation for the Synthesis of the Indole Nucleus. Bioscience, Biotechnology & Biochemistry, 66, 2273-2278, 2002. DOI: 10.1271/bbb.66.2273
37.
Nishikawa, T.; Kajii, S.; Wada, K.; Ishikawa, M.; Isobe, M. Scandium Perchlorate as a Superior Lewis Acid for Regioselective Ring Opening of Aziridine Carboxylate with Indoles, Synthesis, 1658-1662, 2002.
36.
Nishikawa, T.; Asai, M.; Isobe, M. Asymmetric Total Synthesis of 11-Deoxytetrodotoxin, Journal of American Chemical Society, 124, 7847-7852, 2002. DOI: 10.1021/ja0265153
35.
Asai, M.; Nishikawa, T.; Ohyabu, N.; Yamamoto, N.; Isobe, M. Stereocontrolled Synthesis of (-)-5,11-Dideoxytetrodotoxin, Tetrahedron, 57, 4543-4558, 2001. DOI: 10.1016/S0040-4020(01)00382-9
34.
Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Fukuda, Y.; Isobe, M. Synthesis of Common Key Intermediate for (-)-Tetrodotoxin and its Analogs, Tetrahedron, 57, 3875-3883, 2001. DOI: 10.1002/asia.201402202
33.
Nishikawa, T.; Ishikawa, M.; Wada, K.; Isobe, M. Total Synthesis of α-C-mannosyltryptophan, Synlett, 945-947, 2001.
32. Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Isobe, M. Stereoselektive Synthese von (-)-5,11-didesoxytetrodotoxin. Angewandte Chemie, 111, 3268-3271, 1999 (in German). DOI: 10.1002/(SICI)1521-3757(19991018)111:20%3C3268::AID-ANGE3268%3E3.3.CO;2-9 DOI: 10.1002/(SICI)1521-3757(19991018)111:20%3C3268::AID-ANGE3268%3E3.0.CO;2-I
31.
Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Isobe, M. Stereocotrolled Synthesis of (-)-5,11-dideoxytetrodotoxin. Angewandte Chemie International Edition, 38, 3081-3084, 1999 (in English). DOI: 10.1002/(SICI)1521-3773(19991018)38:20%3C3081::AID-ANIE3081%3E3.0.CO;2-6
30.
Isobe, M.; Nishizawa, R.; Nishikawa, T.; Yoza, K. Hydrosilylation of acetylenes with catalytic biscobalthexacarbonyl complex and its application to heteroconjugate addition methodology. Tetrahedron Letters, 40, 6927-6930, 1999. DOI: 10.1016/S0040-4039(99)01228-9
29.
Isobe, M.; Saeeng, R.; Nishizawa, R.; Konobe, M.; Nishikawa, T. Electronic Factors in the C-Glycosidation with Silylacetylene. Chemistry Letters, 467-468, 1999. DOI: 10.1246/cl.1999.467
28.
Nishikawa, T.; Ishikawa, M.; Isobe, M. Synthesis of α-C-Mannosyltryptophan Derivative, Naturally Occurring C-Glycosyl Amino Acid Found in Human Ribonuclease. Synlett, 123-125, 1999.
27.
Nishikawa, T.; Ohyabu, N.; Yamamoto, N.; Isobe, M. New Synthetic Route for Guanidine from Trichloroacetamide for Tetrodotoxin and its Related Compounds. Tetrahedron, 55, 4325-4340, 1999. DOI: 10.1016/S0040-4020(99)00140-4
26.
Nishikawa T.; Isobe, M. Palladium Catalyzed Substitution Reaction of Allylic Derivatives with Tinacetylene. Bioscience, Biotechnology & Biochemistry, 63, 238-242, 1999. DOI: 10.1271/bbb.63.238
25.
Bamba, M.; Nishikawa, T.; Isobe, M. Stereoelectronic and Steric Control in Chiral Cyclohexane Synthesis toward (-)-Tetrodotoxin. Tetrahedron, 54, 6639-6650, 1998. DOI: 10.1016/S0040-4020(98)00331-7
24.
Bamba, M.; Nishikawa, T.; Isobe, M. Stereoelectronic and Steric Effect for Critical Oxidation to the Cyclohexane Derivatives for an Intermediate to (-) -Tetrodotoxin. Synlett, 371-372, 1998.
23.
Nishikawa, T.; Araki, H.; Isobe, M. Novel Stereoselective Reaction of Levoglucosenone with Furfural. Bioscience, Biotechnology & Biochemistry, 62, 190-192, 1998. DOI: 10.1271/bbb.62.190
22.
Nishikawa, T.; Asai, M.; Ohyabu, N.; Isobe, M. Improved Conditions for Facile Overman Rearrangement. Journal of Organic Chemistry, 63, 188-192, 1998. DOI: 10.1021/jo9713924
21.
Unno, R.; Michishita, H.; Inagaki, H.; Suzuki, Y.; Baba, Y.; Jomori, T.; Nishikawa, T.; Isobe, M. Synthesis and Antitumor Effects of Water-Soluble Enediyne Compounds Related to Dynemicin A. Bioorganic & Medicinal Chemistry, 5, 987-9990, 1997. DOI: 10.1016/S0968-0896(97)00037-0
20.
Unno, R.; Michishita, H.; Inagaki, H.; Suzuki, Y.; Baba, Y.; Jomori, T.; Moku, M.; Nishikawa, T.; Isobe, M. Structure-Activity Relationships of Cyclic Enediynes Related to Dynemicin A. Part 2: Synthesis and Antitumor Activity of 9- and 12-Substituted Enediynes. Bioorganic & Medicinal Chemistry, 5, 903-919, 1997. DOI: 10.1016/S0968-0896(97)00027-8
19.
Unno, R.; Michishita, H.; Inagaki, H.; Suzuki, Y.; Baba, Y.; Jomori, T.; Nishikawa, T.; Isobe, M. Structure-Activity Relationships of Cyclic Enediynes Related to Dynemicin A. Part 1: Synthesis and Antitumor Activity of 9-Acetoxy Enediyne Equipped with Aryl Carbamate Moieties. Bioorganic & Medicinal Chemistry, 5, 883-901, 1997. DOI: 10.1016/S0968-0896(97)00026-6
18.
Unno, R.; Michishita, H.; Inagaki, H.; Baba, Y.; Jomori, T.; Nishikawa, T.; Isobe, M. Synthesis and Biological Evaluation of Novel Cyclic Enediyne Compounds Related to Dynemicin A as Antitumor Agents. Chemical & Pharmaceutical Bulletin, 45, 125-133, 1997. DOI: 10.1248/cpb.45.125
17.
Bamba, M.; Nishikawa, T.; Isobe, M. Tin-Assisted Cyclization for Chiral Cyclohexane Synthesis, An Alternative Route to (-)-Tetrodotoxin Skeleton. Tetrahedron Letters, 37, 8199-8202, 1996. DOI: 10.1016/0040-4039(96)01860-6
16.
Nishikawa, T.; Moku, M.; Suzuki, Y.; Isobe, M. Synthesis of Anthraquinone Part of Dynemicin A via Diels-Alder Reaction. Chemistry Letters, 113-114, 1996. DOI: 10.1246/cl.1996.113
15.
Nishikawa, T.; Yoshikai, M.; Obi, K.; Kawai, T.; Unno, R.; Jomori, T.; Isobe, M. Synthesis and Biological Evaluation of Both Enantiomers of Dynemicin A Model Compound. Tetrahedron, 51, 9339-9352, 1995. DOI: 10.1016/0040-4020(95)00521-9
14.
Yamamoto, N.; Nishikawa, T.; Isobe, M. Synthesis of Bicyclic Hydroxy Lactone Intermediate toward (-)-Tetrodotoxin. Synlett, 505-506, 1995.
13.
Nishikawa, T.; Yoshikai, M.; Obi, K.; Isobe, M. Synthesis of Both Enantiomer of Dynemicin A Model Compound. New Remote Asymmetric Induction in Acetylide addition into quinoline Nucleus as Key Step. Tetrahedron Letters, 35, 7997-8000, 1994. DOI: 10.1016/0040-4039(94)80032-4
12.
Nishikawa, T.; Shibuya S.; Hosokawa, S.; Isobe, M. One Pot Synthesis of Haloacetylenes from Trimethylsilylacetylenes. Synlett, 485-486, 1994.
11.
Nishikawa, T.; Shibuya S.; Isobe, M. Cesium Fluoride Promoted Cyclization in the Synthesis of Enediyne Antibiotics. Synlett, 482-484, 1994.
10.
Nishikawa, T.; Isobe, M. Synthetic Studies on Dynemicin A --- New Quinoline Synthesis for C, D and E Rings. Tetrahedron, 50, 5621-5632, 1994. DOI: 10.1016/S0040-4020(01)85633-7
9.
Nishikawa, T.; Ino, A.; Isobe, M. Synthetic Studies on Antibiotic Dynemicin A. Synthesis of Cyclic Enediyne Model Compound of Dynemicin A. Tetrahedron, 50, 1449-1468, 1994. DOI: 10.1016/S0040-4020(01)80629-3
8.
Isobe, M.; Nishikawa, T.; Yamamoto, N.; Tsukiyama, T.; Ino, A.; Okita, T. Methodologies for Synthesis of Heterocyclic Compounds. Journal of Heterocyclic Chemistry, 29, 619-625, 1992. DOI: 10.1002/jhet.5570290303
7.
Nishikawa, T.; Isobe, M.; Goto, T. Synthetic Studies on the Bicyclo[7.3.1]-tridecendiyne System in an Antitumor Antibiotic, Dynemicin A. Synlett, 393-394, 1991.
6.
Nishikawa, T.; Ino, A.; Isobe; M.; Goto, T. Synthesis of a Simple Model Compound of Dynemicin and Cycloaromatization with Pinacol-Pinacolone Rearrangement in the Strained Enediyne Medium Ring. Chemistry Letters, 1271-1274, 1991. DOI: 10.1246/cl.1991.1271
5.
Nishikawa, T.; Isobe, M.; Goto, T. Silyl and Tin Acetylene as Nucleophile toward Acyliminium Cation, a Plausible Key Reaction for Dynemicin, Enediyne Antitumor Antibiotic. Synlett, 99-101, 1991.4.
4.
Isobe, M.; Hirose, Y.; Shimokawa, K.; Nishikawa, T.; Goto, T. Asymmetric Synthesis via Heteroconjugate Addition --- Valinol Template as Oxazolidine Heteroolefin vs. Acetylenic Nucleophiles. Tetrahedron Letters, 31, 5499-5502, 1990. DOI: 10.1016/S0040-4039(00)97882-1
3.
Isobe, M.; Fukuda, Y.; Nishikawa, T.; Chabert, P.; Kawai, T.; Goto, T. Synthetic Studies on (-)-Tetrodotoxin (3) --- Nitrogenation through Overman Rearrangement and Guanidine Ring Formation. Tetrahedron Letters, 31, 3327-3330, 1990. DOI: 10.1016/S0040-4039(00)89056-5
2.
Isobe, M.; Nishikawa, T.; Pikul, S.; Goto, T. Synthetic Studies on Tetrodotoxin [1] --- Stereocontrolled Synthesis of the Cyclohexane Moiety. Tetrahedron Letters, 28, 6485-6488, 1987. DOI: 10.1016/S0040-4039(00)96895-3
1.
Isobe, M.; Fukami, N.; Nishikawa, T.; Goto, T. Synthesis of Chiral Cyclohexanes from Levoglucosenone and its Application to an Indole Alkaloid Reserpine. Heterocycles, 25, 521-532, 1987. DOI: 10.3987/S-1987-01-0521
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