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見出しBCAAの生理機能と代謝制御機構、および癌における代謝状態の改善

研究業績


Shimomura Y, Kitaura Y.(2018) Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions. Pharmacological Research 133:215-217.

北浦 靖之, 下村 吉治(2018) 分岐鎖アミノ酸の分解制御機構とその重要性について 生化学 90(2):234-237.

Xu M, Kitaura Y, Shindo D, Shimomura Y.(2018) Branched-chain amino acid (BCAA) supplementation enhances adaptability to exercise training of mice with a muscle-specific defect in the control of BCAA catabolism. Biosci Biotechnol Biochem. 1:1-4. doi: 10.1080/09168451.2018.1440174.

Yamane T, Morioka Y, Kitaura Y, Iwatsuki K, Shimomura Y, Oishi Y. (2017) Branched-chain amino acids regulate type I tropocollagen and type III tropocollagen syntheses via modulation of mTOR in the skin. Biosci Biotechnol Biochem. 1:doi: 10.1080/09168451.2017.1386084.

下村 吉治
, 北浦 靖之(2017) 食と医療 BCAAの代謝とその生理機能 講談社 3:32-37.

Xu M, Kitaura Y, Ishikawa T, Kadota Y, Terai C, Shindo D, Morioka T, Ota M, Morishita Y, Ishihara K, Shimomura Y. (2017) Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism. PLoS One. 12(7):e0180989. doi: 10.1371/journal.pone.0180989.

北浦 靖之, 下村 吉治
(2017) 非栄養素の分子栄養学 第14章 遺伝子改変動物を用いた分枝アミノ酸の生理機能研究の新展開 建帛社 214-229.

Honda T, Ishigami M, Luo F, Lingyun M, Ishizu Y, Kuzuya T, Hayashi K, Nakano I, Ishikawa T, Feng GG, Katano Y, Kohama T, Kitaura Y, Shimomura Y, Goto H, Hirooka Y.(2017) Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice.Metabolism. 69:177-187

Ishikawa T, Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, Shimomura Y.(2017) Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition. Sci Rep. 7:39825. doi: 10.1038/srep39825.

Tochio T, Kitaura Y, Nakamura S, Sugawa C, Takahashi M, Endo A, Shimomura Y.(2016) An Alteration in the Cecal Microbiota Composition by Feeding of 1-Kestose Results in a Marked Increase in the Cecal Butyrate Content in Rats. PLoS One. 11(11):e0166850.doi: 10.1371/journal.pone.0166850.

Zhen H, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Morishita Y, Ota M, Ito T, Shimomura Y.(2016) mTORC1 is involved in the regulation of branched-chain amino acid catabolism in mouse heart. FEBS Open Bio. 6(1):43-9. doi: 10.1002/2211-5463.12007.

Shimomura Y, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Ota M, Morishita Y, Bariuan JV, Zhen H.(2015) Novel Physiological Functions of Branched-Chain Amino Acids. Journal of Nutritional Science and Vitaminology (Tokyo) 61:Suppl:S112-4. doi: 10.3177/jnsv.61.S112. Review.

下村 吉治, 北浦 靖之, 門田 吉弘(2015) 分岐鎖アミノ酸代謝とインスリン抵抗性 外科と代謝・栄養 49(4):177-182.

Yamada K, Aiba K, Kitaura Y, Kondo Y, Nomura N, Nakamura Y, Fukushi D, Murayama K,Shimomura Y, Pitt J, Yamaguchi S, Yokochi K, Wakamatsu N.(2015) Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase. J Med Genet 52(10):691-8.

下村 吉治北浦 靖之(2015) 分岐鎖アミノ酸(BCAA)の新規生理機能〜バイオテクノロジー研究による証明〜 ILSI Japan 122:16-22.

Zhen H, Nakamura K, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Shimomura Y.(2015) Regulation of the plasma amino acid profile by leucine via the system L amino acid transporter. Biosci Biotechnol Biochem 79(12):2057-62.

Kadota Y, Toyoda T, Hayashi-Kato M, Kitaura Y, Shimomura Y. (2015) Octanoic acid promotes branched-chain amino acid catabolisms via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats. Metabolism 64(9):1157-64.

Kitaura Y, Inoue K, Kato N, Matsushita N, Shimomura Y.(2015) Enhanced oleate uptake and lipotoxicity associated with laurate. FEBS Open Bio 5:485-91.

下村吉治北浦靖之 (2015) アミノ酸サプリメントの功罪ー分岐鎖アミノ酸(BCAA)を中心としてー 体育の科学 65(1):34.

下村吉治北浦靖之 (2014) スポーツ医学的観点からのアミノ酸機能 化学と生物 52(3):143.

Yamada, K., Naiki, M., Hoshino, S., Kitaura, Y., Kondo, Y., Nomura, N., Kimura, R., Fukushi, D., Yamada, Y., Shimozawa, N., Yamaguchi, S., Shimomura, Y., Miura, K., and Wakamatsu, N. (2014) Clinical and Biochemical Analyses of HIBCH Deficiency Causing Leigh-like Disease and Ketoacidosis. Molecular Genetics and Metabolism Reports 1:455.

Furuyashiki, T., Tanimoto, H., Yokoyama, Y., Kitaura, Y., Kuriki, T., and Shimomura, Y. (2014) Effects of ingesting highly branched cyclic dextrin during endurance exercise on rating of perceived exertion and blood components associated with energy metabolism. Biosci Biotechnol Biochem. 78(12):2117.

Hatazawa Y, Tadaishi M, Nagaike Y, Morita A, Ogawa Y, Ezaki O, Takai-Igarashi T, Kitaura Y, Shimomura Y, Kamei Y, Miura S. (2014) PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle. PLoS One 9(3):e91006.

Matsumoto T, Nakamura K, Matsumoto H, Sakai R, Kuwahara T, Kadota Y, Kitaura Y, Sato J, Shimomura Y. (2014) Bolus ingestion of individual branched-chain amino acids alters plasma amino acid profiles in young healthy men. SpringerPlus. 3:doi:10.1186/2193-1801-3-35.

Mochizuki M, Takayanagi H, Yamada S, Osawa T, Kitaura K, Shimomura Y. (2013) Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats. J Phys Fitness Sports Med. 2 (4):509-513.

北浦靖之 (2013) サプリメントのほんととウソ ナップ 65.

Kadota Y, Toyoda T, Kitaura Y, Adams SH, Shimomura Y. (2013) Regulation of hepatic branched-chain α-ketoacid dehydrogenase complex in rats fed a high-fat diet. Obes Res Clin Pract. 7:e439-e444 doi.org/10.1016/j.orcp.2013.07.003

Shimomura, Y., Kitaura, Y., and Shimomura, N. (2012) Effects of protein and amino acid supplementation on muscle protein metabolism in relation to exercise. J. Phys. Fitness Sports Med.1:219-225.

Qin, B., Anderson, R.A., Kuzuya, T., Kitaura, Y., and Shimomura, Y. (2012) Multiple factors and pathways involved in hepatic very low density lipoprotein-apoB100 overproduction in Otsuka Long-Evans Tokushima fatty rats. Atherosclerosis 222:409-416.

Kadota, Y., Kazama, S., Bajotto, G., Kitaura, Y., and Shimomura, Y. (2011) Clofibrate-induced Reduction of Plasma Branched-chain Amino Acid Concentrations Impairs Glucose Tolerance in Rats. JPEN J. Parenter. Enteral. Nutr. 36 (3): 337-343.

Bajotto, G., Sato, Y., Kitaura, Y., and Shimomura, Y. (2011) Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles. Eur. J. Appl. Physiol. 111:1815-1828.

Zhang, Y., Kobayashi, H., Mawatari, M., Sato, J., Bajotto, G., Kitaura, Y., and Shimomura, Y. (2011) Effects of branched-chain amino acid supplementation on plasma concentrations of free amino acids, insulin, and energy substrates in young men. J. Nutr. Sci. Vitaminol. 57(1):114-117.

Doisaki, M., Katano, Y., Nakano, I., Hirooka, Y., Itoh, A., Ishigami, M., Hayashi, K., Goto, H., Fujita, Y., Kadota, Y., Kitaura, Y., Bajotto, G., Kazama, S., Tamura, T., Tamura, N., Feng, G., Ishikawa, N., and Shimomura, Y. (2010) Regulation of hepatic branched-chain a-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease. Biochem. Biophys. Res. Commun. 393: 303-307.

Yoshiki, A., Ike, F., Mekada, K., Kitaura, Y., Nakata, H., Hiraiwa, N., Mochida, K., Ijuin, M., Kadota, M., Murakami, A., Ogura, A., Abe, K., Moriwaki, K., Obata, Y. The mouse resources at the RIKEN BioResource center. Exp. Anim. 58, 85-96 (2009)

Kitaura, Y., Jang, I.K., Wang, Y., Han, Y.C., Inazu, T., Cadera, E.J., Schlissel, M., Hardy, R.R., Gu,H. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 26(5):567-578 (2007)

Huang, F.*, Kitaura, Y.*, Jang, I., Naramura, M., Kole, H.H., Liu, L., Qin, H., Schlissel, M.S., Gu, H. Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. Immunity 25(4):571-581 (2006)
(*These authors contributed equally to this work.)

Pasqualucci, L., Kitaura, Y., Gu, H., Dalla-Favera, R. PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc. Natl. Acad. Sci. U. S. A. 103(2):395-400 (2006)

Kitaura, Y., Satoh, H., Takahashi, H., Shibata, H., Maki, M. Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions. Arch. Biochem. Biophys. 399(1):12-18 (2002)

Maki, M., Kitaura, Y., Satoh, H., Ohkouchi, S., Shibata, H. Structures, functions and molecular evolution of the penta-EF-hand Ca2+-binding proteins. Biochim. Biophys. Acta 1600(1-2):51-60 (2002)

Kitaura, Y., Matsumoto, S., Satoh, H., Hitomi, K., Maki, M. Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner. J. Biol. Chem. 276(17):14053-14058 (2001)

Kitaura, Y., Watanabe, M., Satoh, H., Kawai, T., Hitomi, K., Maki, M. Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region. Biochem. Biophys. Res. Commun. 263(1):68-75 (1999)