名古屋大学大学院生命農学研究科 害虫制御学研究室

Applied Entomology Laboratory, Graduate School of Bioagricultural Sciences, Nagoya University

Research outline

We contribute to Bio-Agricultural Science fields by elucidating physiological function of insects at the molecular level through biochemical, physiological, morphological and toxicological approaches in the context of relationships among insects, as well as with other organisms and xenobiotics. We aim at applying knowledge gained from these studies in pest management.

Insect immune system



Mechanism of insecticide resistance

In insects, some of the enzymes in cytochrome P450 family are the key players in insecticide detoxification.  But our knowledge on the molecular mechanism of insecticide metabolism is still limited.
We are trying to disclose the mechanism of insecticide metabolism, especially in thrips.



Hormonal regulation of insect molting and metamorphosis

Insect molting and metamorphosis are regulated by the molting hormone (ecdysone) and juvenile hormone (JH).  JH is an anti-metamorphic hormone that suppresses metamorphic changes.  Recently, several researchers succeeded in identifying some of the factors in JH signaling pathway: methoprene-toletant (Met) is likely the JH receptor, while Krüppel homolog 1 is a JH-response transcription factor downstream of Met.  Many of these studies were performed by RNAi experiments using the red flour beetle, Tribolium castaneum. 
We are trying to elucidate the molecular mechanism of JH signaling in a variety of pest species.  These studies will help us to develop new insect growth regulators that are specifically effective against the target pest.