現在までの論文・総説・特許等をまとめています。

報文等

・Mechanism of eukaryotic serine racemase-catalyzed serine dehydration. (2020) Ito T, Matsuoka M, Goto M, Watanabe S, Mizobuchi T, Matsushita K, Nasu R, Hemmi H, Yoshimura T. Biochim Biophys Acta Proteins Proteom. May 28:140460.

・ Pyridoxal reductase, PdxI, is critical for salvage of pyridoxal in Escherichia coli. (2020) Ito T & Downs DM. Journal of Bacteriology. 202. e00056-20.

 ・ Inhibition of glycine cleavage system by pyridoxine 5'-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli. (2020)  Ito T, Hori R, Hemmi H, Downs DM, Yoshimura T.  Molecular Microbiology.  2020 113, 270-284.

・ Conserved pyridoxal 5'-phosphate binding protein YggS impacts amino acid metabolism through pyridoxine 5'-phosphate in Escherichia coli.  (2019)  Ito, T., Yamamoto, K., Hori, R., Yamauchi, A., Downs, DM., Hemmi, H. & Yoshimura. T. Applied and Environmental Microbiology. 85, e00430-19.

 ・ Urinary D-serine level as a predictive biomarker for deterioration of renal function in patients with atherosclerotic risk factors. (2019)  Iwakawa, H., Makabe, S., Ito, T., Yoshimura, T. & Watanabe H. Biomarkers. 24, 159-165.

・ Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate. (2018) Hayakawa, H., Motoyama, K., Sobue, F., Ito, T., Kawaide, H., Yoshimura, T. & Hemmi, H. Proceedings of the National Academy of Sciences of the United States of America. 115, 10034-10039.

・  D-Serine metabolism and its importance in development of Dictyostelium discoideum. (2018)  Ito, T., Hamauchi, N., Hagi, T., Morohashi, N., Hemmi, H., Sato, G. Y., Saito, T. & Yoshimura, T. Frontiers in Microbiology. 9: 784

・Production of ophthalmic acid using engineered Escherichia coli . (2018) Ito T, Tokoro M, Hori R, Hemmi H, Yoshimura T. (2018)  Applied and Environmental Microbiology. 84: e02806-17.

・ Utilization of an intermediate of the methylerythritol phosphate pathway, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate, as the prenyl donor substrate for various prenyltransferases. (2018) Hayashi, Y., Ito, T., Yoshimura, T. & Hemmi, H. Bioscience, Biotechnology, and Biochemistry. 82, 993-1002. 

・Occurrence of the (2R,3S)-isomer of 2-amino-3,4-dihydroxybutanoic acid in the mushroom Hypsizygus marmoreus. (2017) Ito T, Yu Z., Yoshino I., Hirozawa Y., Yamamoto K., Shinoda K., Watanabe A., Hemmi H., Asada Y., Yoshimura T. J Agric Food Chem. 65. 131-6139

・Ophthalmic acid accumulation in an Escherichia coli mutant lacking the conserved pyridoxal 5'-phosphate-binding protein YggS. (2016)  Ito T., Yamauchi A., Hemmi H., Yoshimura T.  Journal of Bioscience and Bioengineering.  122. 689-693

・Serine racemase is involved in D-aspartate biosynthesis. (2016) Ito T., Hayashida M., Kobayashi S., Muto N., Hayashi A., Yoshimura T., Mori H. Journal of Biochemistry.　160. 345-353

・Development of a versatile method for targeted gene deletion and insertion by using the pyrF gene in the psychrotrophic bacterium, Shewanella livingstonensis Ac10 . (2016) Ito T., Gong C., Kawamoto J., Kurihara T. Journal of Bioscience and Bioengineering. 122.  645-651

・mTORC1 is involved in the regulation of branched-chain amino acid (BCAA) catabolism in mouse heart. (2016) Zhen H., Kitaura Y., Kadota Y., Ishikawa T., Kondo Y., Xu M., Morishita Y., Ota M., Ito T., Shimomura Y. FEBS Open Bio. 6. 43-49

・Eukaryotic d-Serine Dehydratase.  (2016) Ito, T. Yoshimura, T Ishida, H Tanaka - D-Amino Acids, 2016 - Springer

・A New Member of MocR/GabR-type PLP-Binding Regulator of D-Alanyl-D-Alanine Ligase in Brevibacillus brevis. (2015) Takenaka T., Ito T*., Miyahara I., Hemmi H., Yoshimura T. FEBS J. 282. 4201-4217.

・Domain characterization of Bacillus subtilis GabR, a pyridoxal  5'-phosphate-dependent transcriptional regulator. (2015) Okuda K., Ito T., Goto M., Takenaka T., Hemmi H., Yoshimura T. Journal of Biochemistry. 158. 225-234 [PubMed]

・PEGylated D-Serine Dehydratase as a D-Serine Reucing Agent. (2015) Ito T., Takada H., Isobe K., Suzuki M., Kitaura Y., Hemmi H., Matsuda T., Sasabe J., Yoshimura T. Journal of Pharmaceutical and Biomedical Analysis. 116. 34-9 [PubMed]

・Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator. (2015) Okuda K., Kato S., Ito T., Shiraki S., Kawase Y., Goto M., Kawashima S., Hemmi H., Fukada H., Yoshimura T. Molecular Microbiology. 95. 245-257 [PubMed]

・ Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1), a putative aspartate racemase? (2015) Tanaka-Hayashi A., Hayashi S., Inoue R., Ito T., Kouno K., Yoshida T., Watanabe M., Yoshimura T., Mori H. Amino Acids. 47. 79-86 [PubMed]

・酵母D-セリンデヒドラターゼの反応機構 (Reaction mechanism of yeast D-serine dehydratase) (2014) 松岡舞, 伊藤智和, 吉村徹. Vitamins. 88 (11) 576-579

・ビタミンB6が担うD-セリンの機能と代謝：セリンラセマーゼとD-セリンデヒドラターゼ (Vitami B6-dependet enzymes involved in D-serine metabolism: serine racemase and D-serine dehydratase)  (2014) 吉村徹, 伊藤智和. Vitamins. 88 (9) 462-468

・真核生物型セリンラセマーゼの反応機構 (Reaction mechanism of eukaryotic serine racemase) (2014) 吉村徹, 伊藤智和. Vitamins. 88 (8) 425-428

・Reaction mechanism of Zn²⁺-dependent D-serine dehydratase: role of a conserved tyrosine residue interacting with pyridine ring nitrogen of pyridoxal 5'-phosphate. (2014) Ito T., Matsuoka M., Koga K., Hemmi H., Yoshimura T.Journal of Biochemistry. 156. 173-180 [PubMed]

・D-アミノ酸代謝関連酵素--構造・機能研究の最前線--「D－セリンデヒドラターゼ」について執筆担当, BIOINDUSTRY, シーエムシー出版, 2014年3月号

・Conserved pyridoxal protein that regulates Ile and Val metabolism. (2013) Ito T., Iimori J., Takayama S., Moriyama A., Yamauchi A., Hemmi H., Yoshimura T. Journal of Bacteriology. 195. 5439-5449 [PubMed]

・Catalytic mechanism of serine racemase from Dictyostelium discoideum. (2013) Ito T., Maekawa M., Hyashi S., Goto M., Hemmi H., Yoshimura T. Amino Acids. 44. 1073-84 [PubMed]

・Metal ion dependency of serine racemase from Dictyostelium discoideum. (2012) Ito T., Murase H., Maekawa M., Hayashi S., Maki M., Hemmi H., Yoshimura T. Amino Acids. 43. 1567-1576 [PubMed]

・Role of zinc ion for catalytic activity in D-serine dehydratase from Saccharomyces cerevisiae. (2012) Ito T., Koga K., Hemmi H., Yoshimura T. FEBS J. 279. 612-624 [PubMed]

・哺乳類のアスパラギン酸ラセマーゼ （Aspartate racemase of mammals)  (2011) 伊藤智和, 吉村徹 Vitamins. 85. 661-662

・右手型アミノ酸の役割　（2010） 伊藤智和 生物工学会誌　88. 613

・A highly sensitive enzymatic assay for D- and total serine detection using D-serine dehydratase from Saccharomyces cerevisiae (2010) Naka T., Ito T., Hemmi H., Yoshimura T. Journal of molecular catalysis. B, Enzymatic. 67. 150-154 [doi:10.1016/j.molcatb.2010.08.002]

・The implication of YggT of Escherichia coli in osmotic regulation (2009) Ito T., Uozumi N., Nakamura T., Takayama S., Matsuda N., Aiba H., Hemmi H., Yoshimura T.  Bioscience, Biotechnology, and Biochemistry. 73. 2698-704. [PubMed]

・A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae (2008) Ito T., Hemmi H., Kataoka K., Mukai Y., Yoshimura T. Biochemical Journal 409, 399-406. [PubMed]

・Saccharomyces cerevisiaeの新奇D-セリンデヒドラターゼとD-セリン定量への応用 (A novel D-serine dehydratase from Saccharomyces cerevisiae and its application to D-serine assay)  (2008) 伊藤智和, 吉村徹 Vitamins. 82. 349-351

・Enzymatic assay of D-serine using D-serine dehydratase from Saccharomyces cerevisiae. (2007) Ito T., Takahashi K., Naka T., Hemmi H., Yoshimura T. Analytical biochemistry. 371. 167-72. [PubMed]

特許等

D-セリンデヒドラターゼ及びその利用　（特許第５２１８９４９号（Ｐ５２１８９４９））

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