{"id":67,"date":"2017-01-19T09:09:47","date_gmt":"2017-01-19T00:09:47","guid":{"rendered":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/?page_id=67"},"modified":"2024-12-09T09:51:04","modified_gmt":"2024-12-09T00:51:04","slug":"achievement","status":"publish","type":"page","link":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/achievement\/","title":{"rendered":"\u696d\u7e3e"},"content":{"rendered":"<h2>\u4ee3\u8868\u7684\u306a\u8ad6\u6587<\/h2>\n<ul class=\"ul_B\">\n<li>Masakazu Nambo, <span style=\"text-decoration: underline;\"><strong>Taeko Nishiwaki-Ohkawa<\/strong><\/span>, Akihiro Ito, Zachary T. Ariki, Yuka Ito, Yuuki Kato, Muhammad Yar, Jacky C. -H. Yim, Emily Kim, Elizabeth Sharkey, Keiko Kano, Emi Mishiro-Sato, Kosuke Okimura, Michiyo Maruyama, Wataru Ota, Yuko Furukawa, <span style=\"text-decoration: underline;\"><strong>Tomoya Nakayama<\/strong><\/span>, Misato Kobayashi, Fumihiko Horio, Ayato Sato, Cathleen M. Crudden, <span style=\"text-decoration: underline;\"><strong>Takashi Yoshimura<\/strong><\/span>. Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261. <a href=\"https:\/\/www.nature.com\/articles\/s43856-024-00574-z#citeas\"><i>Commun Med<\/i>\u00a0<b>4<\/b>, 152 (2024).<\/a><\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Tomoya Nakayama<\/strong><\/span>, Miki Tanikawa, Yuki Okushi, Thoma Itoh, Tsuyoshi Shimmura, Michiyo Maruyama, Taiki Yamaguchi, Akiko Matsumiya, Ai Shinomiya, Ying-Jey Guh, Junfeng Chen, Kiyoshi Naruse, Hiroshi Kudoh, Yohei Kondo, Honda Naoki, Kazuhiro Aoki, Atsushi J. Nagano, <span style=\"text-decoration: underline;\"><strong>Takashi Yoshimura<\/strong><\/span>. A transcriptional program underlying the circannual rhythms of gonadal development in medaka. <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2313514120\"><em><strong>Proceedings of the National Academy of Sciences of the United States of America<\/strong><\/em> 120(52), e2313514120 (2023).<\/a><\/li>\n<li><span style=\"font-weight: 400;\">Junfeng Chen, Yuma Katada, Kousuke Okimura, Taiki Yamaguchi, Ying-Jey Guh, <span style=\"text-decoration: underline;\"><strong>Tomoya Nakayama<\/strong><\/span>, Michiyo Maruyama, Yuko Furukawa, Yusuke Nakane, Naoyuki Yamamoto, Yoshikatsu Sato, Hironori Ando, Asako Sugimura, Kazufumi Tabata, Ayato Sato, <span style=\"text-decoration: underline;\"><strong>Takashi Yoshimura<\/strong><\/span>. Prostaglandin E2 synchronizes lunar-regulated beach-spawning in grass puffers. <a href=\"https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(22)01604-9\"><em><strong>Current Biology<\/strong><\/em> 32, 1-9 (2022).<\/a><\/span><\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Nakayama T<\/strong><\/span>, Okimura K, Shen J, Guh YJ, Tamai TK, Shimada A, Minou S, Okushi Y, Shimmura T, Furukawa Y, Kadofusa N, Sato A, Nishimura T, Tanaka M, Nakayama K, Shiina N, Yamamoto N, Loudon AS, <span style=\"text-decoration: underline;\"><strong>Nishiwaki-Ohkawa T<\/strong><\/span>, Shinomiya A, Nabeshima T, Nakane Y, <span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nSeasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior.<br \/>\n<a href=\"https:\/\/www.pnas.org\/content\/early\/2020\/04\/09\/2000278117.long\"><em><strong>Proceedings of the National Academy of Sciences of the United States of America <\/strong><\/em>\u00a0[Epub ahead of print] (2020).<\/a><\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Nakayama T<\/strong><\/span>, Shimmura T, Shinomiya A, Okimura K, Takehana Y, Furukawa Y, Shimo T, Senga T, Nakatsukasa M, Nishimura T, Tanaka M, Okubo K, Kamei Y, Naruse K, <span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nSeasonal regulation of the lncRNA LDAIR modulates self-protective behaviours during the breeding season.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41559-019-0866-6\"><em><strong>Nature Ecology &amp; Evolution<\/strong><\/em> [Epub ahead of print] (2019).<\/a><br \/>\nFeatured in <a href=\"https:\/\/natureecoevocommunity.nature.com\/users\/253536-tomoya-nakayama\/posts\/47355-long-non-coding-rna-ldair-is-involved-in-seasonal-adaptation-in-medaka-fish\">BEHIND THE PAPER<\/a><\/li>\n<\/ul>\n<ul class=\"ul_B\">\n<li>Tamai TK, Nakane Y, Ota W, Kobayashi A, Ishiguro M, Kadofusa N, Ikegami K, Yagita K, Shigeyoshi Y, Sudo M, <span style=\"text-decoration: underline;\"><strong>Nishiwaki-Ohkawa T<\/strong><\/span>, Sato A, <span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong>.<\/span><br \/>\nIdentification of circadian clock modulators from existing drugs.<br \/>\n<a href=\"http:\/\/embomolmed.embopress.org\/content\/early\/2018\/04\/16\/emmm.201708724.long\"><em><strong>EMBO Molecular Medicine<\/strong><\/em>\u00a0e8724\u00a0(2018).<\/a><\/li>\n<li>Shimmura\u00a0T, <span style=\"text-decoration: underline;\"><strong>Nakayama T<\/strong><\/span>, Shinomiya A, Fukamachi S, Yasugi M, Watanabe E, Shimo T, Senga T, Nishimura T, Tanaka M, Kamei Y, Naruse K,\u00a0<span style=\"text-decoration: underline;\"><b>Yoshimura<\/b>\u00a0<strong>T<\/strong><\/span>.<br \/>\nDynamic plasticity in phototransduction regulates seasonal changes in color perception.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-017-00432-8\"><em><strong>Nature Communications\u00a0<\/strong><\/em>8, 412 (2017).<\/a><\/li>\n<li>Maeda R, Shimo T, Nakane Y, Nakao N, <span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nOntogeny of the Saccus Vasculosus, a Seasonal Sensor in Fish.<br \/>\n<a href=\"https:\/\/academic.oup.com\/endo\/article-abstract\/156\/11\/4238\/2423112\/Ontogeny-of-the-Saccus-Vasculosus-a-Seasonal?redirectedFrom=fulltext\"><strong><em>Endocrinology<\/em><\/strong> 156, 4238-43 (2015)<\/a><\/li>\n<li>Shimmura T, Ohashi S, <span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nThe highest-ranking rooster has priority to announce the break of dawn.<br \/>\n<a href=\"http:\/\/www.nature.com\/articles\/srep11683\"><strong><em>Scientific Reports<\/em><\/strong>\u00a05, 11683 (2015)<\/a><\/li>\n<li>Oshima T, Yamanaka I, Kumar A, Yamaguchi J, <span style=\"text-decoration: underline;\"><strong>Nishiwaki-Ohkawa T<\/strong><\/span>, Muto K, Kawamura R, Hirota T, Yagita K, Irle S, Kay SA, <span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>, Itami K.<br \/>\nC-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.<br \/>\n<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ange.201502942\/full\"><em><strong>Angewandte Chemie International Edition<\/strong><strong>\u00a0in English<\/strong><\/em> 54, 7193-7 (2015)<\/a><\/li>\n<li>Ikegami K, Liao XH, Hoshino Y, Ono H, Ota W, Ito Y, <span style=\"text-decoration: underline;\"><strong>Nishiwaki-Ohkawa T<\/strong><\/span>, Sato C, Kitajima K, Iigo M, Shigeyoshi Y, Yamada M, Murata Y, Refetoff S,\u00a0<span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nTissue-specific post-translational modification allows functional targeting of thyrotropin<br \/>\n<a href=\"http:\/\/www.cell.com\/cell-reports\/abstract\/S2211-1247(14)00860-2\"><em><strong>Cell Reports<\/strong><\/em>\u00a09, 1-9 (2014)<\/a><br \/>\n<a href=\"http:\/\/www.cell.com\/cell-reports\/issue?pii=S2211-1247(14)X0021-5\">Selected for cover picture<\/a><\/li>\n<li>Nakane Y, Shimmura T, Abe H,\u00a0<span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nIntrinsic photosensitivity of deep brain photoreceptor.<br \/>\n<a href=\"http:\/\/www.cell.com\/current-biology\/abstract\/S0960-9822(14)00603-4\"><strong><em>Current Biology<\/em><\/strong>\u00a024, R596-R597 (2014)<\/a><br \/>\nFeatured in <a href=\"http:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(14)00602-2\">Current Biology Dispatch<\/a> and <a href=\"http:\/\/www.cell.com\/current-biology\/issue?pii=S0960-9822(14)X0013-8\">selected for cover picture<\/a><\/li>\n<li>Nakane Y, Ikegami K, Iigo M, Ono H, Takeda K, Takahashi D, Uesaka M, Kimijima M, Hashimoto R, Arai N, Suga T, Kosuge K, Abe T, Maeda R, Senga T, Amiya N, Azuma T, Amano M, Abe H, Yamamoto N, <span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nThe saccus vasculosus of fish is a sensor of seasonal changes in day length.<br \/>\n<a href=\"http:\/\/www.nature.com\/articles\/ncomms3108\"><strong><em>Nature Communications<\/em><\/strong>\u00a04, 2108 (2013)<br \/>\n<\/a>Featured article in Nature Communications,\u00a0<a href=\"http:\/\/www.natureasia.com\/ja-jp\/research\/highlight\/8546\">Nature Japan\u300c\u6ce8\u76ee\u306e\u30cf\u30a4\u30e9\u30a4\u30c8\u300d<\/a><\/li>\n<li>Shimmura T,<strong>\u00a0<span style=\"text-decoration: underline;\">Yoshimura T<\/span><\/strong>.<br \/>\nCircadian clock determines the timing of rooster crowing.<br \/>\n<a href=\"http:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(13)00186-3\"><strong><em>Current Biology<\/em><\/strong>\u00a023, R231-R233 (2013)<\/a><br \/>\n<a href=\"http:\/\/www.cell.com\/current-biology\/issue?pii=S0960-9822(13)X0006-5\">Selected for cover picture<\/a><\/li>\n<li>Nakane Y, Ikegami K, Ono H, Yamamoto N, Yoshida S, Hirunagi K, Ebihara S, Kubo Y,\u00a0<span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nA mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds.<br \/>\n<a href=\"http:\/\/www.pnas.org\/content\/107\/34\/15264.full\"><b><i>Proceedings of the National Academy of Sciences of the United States of America<\/i><\/b> 107, 15264-15268 (2010)<\/a><br \/>\n<a href=\"http:\/\/science.sciencemag.org\/content\/329\/5994\/twil.full\">SCIENCE (Aug 20, 2010) Editor&#8217;s Choice<\/a><\/li>\n<li>Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K,\u00a0<span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>, Nabeshima T, Ebihara S.<br \/>\nIdentification of Usp46, encoding a ubiquitin specific peptidase, as a quantitative trait gene regulating mouse immobile behavior in the tail suspension test and forced swimming test.<br \/>\n<a href=\"http:\/\/www.nature.com\/ng\/journal\/v41\/n6\/full\/ng.344.html\"><strong><em>Nature Genetics\u00a0<\/em><\/strong>41, 688-695 (2009)<\/a><\/li>\n<li>Yasuo S,\u00a0<span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>, Ebihara S, Korf HW.<br \/>\nMelatonin transmits photoperiodic signals through the MT1 melatonin receptor<em>.<\/em><br \/>\n<a href=\"http:\/\/www.jneurosci.org\/content\/29\/9\/2885.long\"><strong><em>Journal of Neuroscience<\/em>\u00a0<\/strong>29, 2885-2889 (2009)<\/a><\/li>\n<li>Ono H, Hoshino Y, Yasuo S, Watanabe M, Nakane Y, Murai A, Ebihara S, Korf HW,\u00a0<span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nInvolvement of thyrotropin in photoperiodic signal transduction in mice.<br \/>\n<a href=\"http:\/\/www.pnas.org\/content\/105\/47\/18238.full\"><em><strong>Proceedings of the National Academy of Sciences of the United States of America<\/strong><\/em> 105, 18238-18242 (2008)<\/a><\/li>\n<li><b><span style=\"text-decoration: underline;\">Nishiwaki T<\/span>,<\/b> Satomi Y, Kitayama Y, Terauchi K, Kiyohara R, Takao T, Kondo T.<br \/>\nA sequential program of dual phosphorylation of KaiC as a basis for circadian rhythm in cyanobacteria.<br \/>\n<a href=\"http:\/\/emboj.embopress.org\/content\/26\/17\/4029.long\"><b><i>EMBO J<\/i><\/b> 26, 4029-4037 (2007)<\/a><\/li>\n<li>Nakao N, Ono H, Yamamura T, Anraku T, Takagi T, Higashi K, Yasuo S, Katou Y, Kageyama S, Uno Y, Kasukawa T, Iigo M, Sharp PJ, Iwasawa A, Suzuki Y, Sugano S, Niimi T, Mizutani M, Namikawa T, Ebihara S, Ueda HR,\u00a0<span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>.<br \/>\nThyrotrophin in the pars tuberalis triggers photoperiodic response.<br \/>\n<a href=\"http:\/\/www.nature.com\/nature\/journal\/v452\/n7185\/abs\/nature06738.html\"><strong><em>Nature\u00a0<\/em><\/strong>452, 317-322 (2008)<\/a><br \/>\n<a href=\"http:\/\/www.nature.com\/nature\/journal\/v452\/n7185\/full\/452294a.html\">News &amp; Views<\/a>,\u00a0<a href=\"http:\/\/f1000.com\/guardpages\/evaluation\/1103706\/\/article\/article.asp%253Fid%253D1103706%2526view%253D%2526style%253D\">Faculty of 1000 Biology &#8220;Exceptional&#8221;<\/a><\/li>\n<li><b><span style=\"text-decoration: underline;\">Nishiwaki T<\/span>, <\/b>Satomi Y, Nakajima M, Lee C, Kiyohara R, Kageyama H, Kitayama Y, Temamoto M, Yamaguchi A, Hijikata A, Go M, Iwasaki H, Takao T, Kondo T.<br \/>\nRole of KaiC phosphorylation in the circadian clock system of Synechococcus elongatus PCC 7942.<br \/>\n<a href=\"http:\/\/www.pnas.org\/content\/101\/38\/13927\"><em><strong>Proceedings of the National Academy of Sciences of the United States of America<\/strong><\/em> 101, 13927-13932 (2004)<\/a><\/li>\n<li><span style=\"text-decoration: underline;\"><strong>Yoshimura T<\/strong><\/span>, Yasuo S, Watanabe M, Iigo M, Yamamura T, Hirunagi K, Ebihara S.<br \/>\nLight-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds.<br \/>\n<a href=\"http:\/\/www.nature.com\/nature\/journal\/v426\/n6963\/abs\/nature02117.html\"><strong><em>Nature\u00a0<\/em><\/strong>426, 178-181 (2003)<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u4ee3\u8868\u7684\u306a\u8ad6\u6587 Masakazu Nambo, Taeko Nishiwaki-Ohkawa, Akihiro Ito, Zachary T. Ariki, Yuka Ito, Yuuki Kato, Muhammad Y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-67","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/wp-json\/wp\/v2\/pages\/67","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/wp-json\/wp\/v2\/comments?post=67"}],"version-history":[{"count":28,"href":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/wp-json\/wp\/v2\/pages\/67\/revisions"}],"predecessor-version":[{"id":1499,"href":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/wp-json\/wp\/v2\/pages\/67\/revisions\/1499"}],"wp:attachment":[{"href":"https:\/\/www.agr.nagoya-u.ac.jp\/~aphysiol\/wp-json\/wp\/v2\/media?parent=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}