Laboratory of Animal Nutrition, Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University


原著論文・著書 | 受賞(学会賞など) | 受賞(学会発表など)



  • Kawade, N., Murai, A. Suzuki W., Takeuchi K., Kobayashi, M., and Horio, F. Ascorbic acid deficiency induces hepatic and intestinal expression of inflammation-related genes irrespective of the presence or absence of gut microbiota in ODS rats. J. Nutr.Biochem. (2020). doi:10.1016/j.jnutbio.2020.108485.
  • Kobayashi, M., Ueda H., Babaya N., Itoi-Babaya M., Noso S., Fujisawa T., Horio, F., and Ikegami H. Type 2 diabetes susceptibility genes on mouse chromosome 11 under high sucrose environment. BMC Genet., 21(1):81. (2020). doi: 10.1186/s12863-020-00888-6.
  • Masuya T., Suzuki M., Tsujimura J., Kanamori S., Miyasaka Y., Ohno T., Murai A., Horio F., and Kobayashi, M. Ablation of Iah1, a candidate gene for diet-induced fatty liver, does not affect liver lipid accumulation in mice. PLoS One. 15(5):e0233087. (2020) doi: 10.1371/journal.pone.0233087.
  • Murai A, Hamano T, Kakiuchi M, Kobayashi M, Horio F. Evaluation of a receptor gene responsible for maternal blood IgY transfer into egg yolks using bursectomized IgY-depleted chickens. Poult Sci. 99:1914-1920. (2020)
  • Ikeda S, Takahashi S, Suzuki N, Hanzawa F, Horio F, Oda H. Gut Microbiota Is Not Involved in the Induction of Acute Phase Protein Expression Caused by Vitamin C Deficiency. J Nutr Sci Vitaminol (Tokyo).  66:19-23. (2020)
  • Takeshita N, Kawade N, Suzuki W, Hara S, Horio F, Ichinose H. Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats. Neurosci Lett. 715:134656. (2020)


  • Kawade, N., Murai, A., Suzuki, W., Tokuda, Y., Kobayashi, M., and Horio, F. Ascorbic acid deficiency increases hepatic expression of acute phase proteins through the intestine-derived IL-6 and hepatic STAT3 pathway in ODS rats. J. Nutr. Biochem., 70: 116-124. (2019).


  • Kawade, N., Tokuda, Y., Tsujino, S., Aoyama, H., Kobayashi, M., Murai, A. and Horio, H. Dietary Intake of Ascorbic Acid Attenuates Lipopolysaccharide-Induced Sepsis and Septic Inflammation in ODS Rat.J. Nutr. Sci. Vitaminol. 64: 404-411. (2018)
  • Murai, A., Kitahara, K., Terada, H., Ueno, A., Ohmori, Y., Kobayashi, M. and Horio, F. Ingestion of paddy rice increases intestinal mucin secretion and goblet cell number and prevents dextran sodium sulfate-induced intestinal barrier defect in chickens. Poult. Sci., 97: 3577–3586 (2018).
  • Maegawa, T., Miyasaka, Y., Kobayashi, M., Babaya, N., Ikegami, H.,Horio, F.,Takahashi, M., Ohno, T.: Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11. Mamm Genome, 29:273-280. (2018)


  • Kobayashi, M., Kurata, T., Hamana, Y., Hiramitsu,M., Inoue,T., Murai, A. and Horio, F.: Coffee ingestion suppresses hyperglycemia in streptozotocin-induced diabetic mice. J. Nutr. Sci. Vitaminol. 63:200-207. (2017)
  • Ohno, T., Maegawa, T., Katoh, H., Miyasaka, Y., Suzuki, M., Kobayashi, M., Horio, F.: A new missense mutation in the paired domain of the mouse Pax3 gene. Exp Anim. 66:245-250. (2017)
  • 村井篤嗣.IgY抗体の卵黄への輸送機構の解明とその知見の応用. 畜産技術. 3月号, 6-11 (2017)


  • Suzuki, M., Kobayashi, M., Ohno, T., Kanamori, S., Tateishi, S., Murai, A. and Horio, F.:Genetic dissection of the fatty liver QTL Fl1sa by using congenic mice and identification of candidate genes in the liver and epididymal fat. BMC Genet. 17(1): 145 (2016)
  • Kobayashi, M., Suzuki, M., Ohno, T., Tsuzuki, K., Taguchi, C., Tateishi, S., Kawada, T., Kim, Y.I., Murai, A. and Horio, F.: Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12.BMC Genet. 17(1): 73 (2016)
  • Murai, A., Kakiuchi, M., Hamano, T., Kobayashi, M., Tsudzuki, M., Nakano, M., Matsuda, Y. and Horio, F.: An ELISA for quantifying quail IgY and characterizing maternal IgY transfer to egg yolk in several quail strains. Vet. Immunol. Immunopathol., 175: 16-23 (2016).
  • Murai, A., Kitahara, K., Okumura, S., Kobayashi, M. and Horio, F.: Oral antibiotics enhance antibody responses to keyhole limpet hemocyanin in orally but not muscularly immunized chickens. Anim. Sci. J., 87: 257–65. (2016)
  • 村井篤嗣「脂質」ならびに「ウズラ」. 動物の栄養 第2版. 朝倉書店. (2016)


  • 堀尾文彦
    ビタミンCの生合成制御と生体防御・疾患に関わる生理機能の解析 ビタミン、89(11),528-536(2015)
  • Tokuda, Y., Miura, N., Kobayashi, M., Hoshinaga, Y., Murai, A., Aoyama, H., Ito, H., Morita, T. and Horio, F.: Ascorbic acid deficiency increases endotoxin influx to portal blood and liver inflammatory gene expressions in ODS rats. Nutrition, 31(2):373-379 (2015)


  • Kobayashi, M., Ohno, T., Ihara, K., Murai, A., Kumazawa, M., Hoshino, H., Iwanaga, K., Iwai, H., Hamana, Y., Ito, M., Ohno, K. and Horio, F.: Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains. PLoS One, 9(5),e96271(2014)
  • Tachibana N, Yamashita Y, Nagata M, Wanezaki S, Ashida H, Horio F, Kohno M.: Soy β-conglycinin improves glucose uptake in skeletal muscle and ameliorates hepatic insulin resistance in Goto-Kakizaki rats.  Nutr Res. 34(2):160-167 (2014)
  • Kobayashi, M., Hoshinaga, Y., Miura, N., Tokuda, Y., Shigeoka, S., Murai, A., Horio, F.: Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats.  Biosci.Biotechnol.Biochem.78(6):1060-1066 (2014)
  • 村井篤嗣
    母ドリの卵黄へのIgY 取り込みの分子基盤 栄養生理研究会報 58(1):9-17 (2014)
  • 村井篤嗣
    卵の特徴. ニワトリの科学 朝倉書店 126-134 (2014)


  • Jin W, Yamada K, Ikami M, Kaji N, Tokeshi M, Atsumi Y, Mizutani M, Murai A, Okamoto A, Namikawa T, Baba Y, Ohta M.: Application of IgY to sandwich enzyme-linked immunosorbent assays, lateral flow devices, and immunopillar chips for detecting staphylococcal enterotoxins in milk and dairy products. J. Microbiol. Methods 92: 323-331. (2013)
  • Yamada K, Jin W, Ohkura T, Murai A, Hayakawa R, Kinoshita K, Mizutani M, Okamoto A, Namikawa T, Ohta M.: Detection of Methicillin-resistant Staphylococcus aureus using specific anti-PBP2a chicken IgY antibody. Jpn. J. Infect. Dis. 66: 103-108. (2013)
  • Murai A: Maternal transfer of immunoglobulins into egg yolks of birds. J. Poult. Sci.50: 185-193. (2013)
  • Takimoto T, Doi K, Kobayashi M, Horio F, Murai A.: Amino acid substitution in the Cυ3 domain causes either elevation or reduction of IgY uptake into egg yolks of quail. Vet Immunol Immunopathol. 153(3-4), 289-97 (2013)  doi: 10.1016/j.vetimm.2013.03.011.
  • Murai A, Murota R, Doi K, Yoshida T, Aoyama H, Kobayashi M, Horio F.
    Avian IgY is selectively incorporated into the egg yolks of oocytes by discriminating Fc amino acid residues located on the Cu3/Cu4 interface. Develop. Comp. Immunol. 39(4): 378-87 (2013) doi: 10.1016/j.dci.2012.
  • 堀尾文彦
    ビタミンCとハプトグロビンの遺伝子多型 ビタミン、87(9),497-500(2013)


  • Goto, T., Takahashi, N., Kato, S., Kim, Y.I., Kusudo, T., Taimatsu, A., Egawa, K., Kang, M.S., Hiramatsu, T., Sakamoto, T., Uemura, T., Hirai, T., Kobayashi, M., Horio, F., Kawada, T.: Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice.  J.Agric.Food Chem., 60: 11952-11958 (2012)
  • Minakata K, Yamagishi I, Nozawa H, Gonmori K, Hasegawa K, Suzuki M, Horio F, Watanabe K, Suzuki O.  Simultaneous determination of coinage metals, copper, silver, and gold in tissues using electrospray ionization tandem mass spectrometry.  Forensic Toxicol., 30: 149-155 (2012)
  • Kobayashi M, Kawashima H, Takemori K, Ito H, Murai A, Yamada K, Uemura D, Horio F.
    Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-Ay mice. Biochem.Biophys.Res.Commun. 427: 299-304 (2012) doi: 10.1016/j.bbrc.2012.09.045.
  • Ohno T, Hata K, Baba T, Io F, Kobayashi M, Horio F, Nishimura M. 
    Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits. Mamm.Genome 23:764-769 (2012)
  • Kobayashi M, Matsuda Y, Iwai H, Yamashita Y, Ashida H, Murai A, Horio F.
    Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-Ay mice  J Nutr Sci Vitaminol (Tokyo) 58(6):408-14 (2012)
  • 村井篤嗣 (2012)
    日本飼養標準・家禽(2011年版)(独立行政法人 農業・食品産業技術総合研究機構編, 分担執筆)社団法人中央畜産会
  • 小林 美里、堀尾文彦
    2型糖尿病動物モデルを用いた糖尿病発症因子解析の最新動向 最新臨床糖尿病学(上) 日本臨床 202-206 (2012)


  • Matsunaga M, Horio F, Takahashi N, Kawada T.
    Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways. Am J Physiol Endocrinol Metab. (2011) 301:E1022-1032
  • 堀尾文彦、小林美里 (2011) コーヒーの2型糖尿病抑制効果とその作用機構、バイオサイエンスとバイオインダストリー、11月号
  • Matsuda Y, Kobayashi M, Yamauchi R, Ojika M, Hiramitsu M, Inoue T, Katagiri T, Murai A, Horio F. Coffee and caffeine improve insulin sensitivity and glucose tolerance in C57BL/6J mice fed a high-fat diet. Biosci Biotechnol Biochem. (2011) 75:2309-15.


  • Kobayashi M, Ohno T, Hada N, Fujiyoshi M, Kuga M, Nishimura M, Murai A, Horio F. Genetic analysis of abdominal fat distribution in SM/J and A/J mice. J.Lipid Res. (2010) 51:3463-3469 doi: 10.1194/jlr.M009563.
  • Kitaguchi, K., Bae, H.-D., Sasanami, H., Kobayashi, M., Horio, F. and Murai, A. Microscopic detection of IgY-Fc binding signal in the inner layers of ovarian follicular tissues in quail. Anim. Sci. J.(2010) 81:580-585 doi: 10.1111/j.1740-0929.2010.00768.x.
  • Bae, H.-D., Honda, H., Murota, R., Kobayashi, M., Horio, F. and Murai, A.  Production of recombinant chicken IgY-Fc and evaluation of its transport ability into avian egg yolks. J. Poult. Sci.(2010) 47:256-261.*論文賞を受賞
  • Tachibana, N., Iwaoka, Y., Hirotsuka, M., Horio,F. and Kohno, M. b-Conglycinin lowers very-low-density lipoprotein-triglyceride levels by increasing adiponectin and insulin sensitivity in rats. Biosci.Biotechnol.Biochem.(2010)74: 1250-1255
  • Bae, H.-D., Kobayashi, M., Horio, F. and Murai, A. Identification of the amino acid residues involved in human IgG transport into egg yolks of Japanese quail (Coturnix japonica). Mol. Immunol. (2010) 47: 1404-1410. doi: 10.1016/j.molimm.2010.02.011.
  • Yamauchi, R., Kobayashi, M., Matsuda, Y., Ojika, M., Shigeoka, S., Yamamoto, Y., Tou, Y., Inoue, T., Katagiri, T., Murai, A. and Horio, F. Coffee and caffeine ameliorate hyperglycemia, fatty liver, and inflammatory adipocytokine expression in spontaneously diabetic KK-Ay mice. J.Agric.Food Chem.(2010) 58,5597-5603
  • Takikawa, M., Inoue, S., Horio, F. and Tsuda, T. Dietary antthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J.Nutr.(2010) 140,527-533
  • 村井篤嗣 鳥類卵黄内への物質輸送機構:特に抗体の輸送機構を中心として.
科学飼料 (2010) 55: 187-190


  • 堀尾文彦教授が平成30年度 日本栄養・食糧学会 学会賞を受賞
  • 堀尾文彦教授が平成27年度 日本ビタミン学会 学会賞を受賞
  • 小林美里助教が平成26年度 日本栄養・食糧学会 奨励賞を受賞
  • 村井篤嗣准教授が平成24年度 日本家禽学会 学会賞を受賞


  • 川出野絵さん(D2)が平成30年度日本栄養・食糧学会(岡山県立大)で学生優秀発表賞を受賞
  • 垣内美紗子さん(M2)が平成28年東海畜産学会(WINCあいち)で優秀発表賞を受賞
  • 鈴木京さん(D2)が第69回日本栄養・食糧学学会中部支部大会(静岡県立大学)で優秀発表賞を受賞
  • 濱野貴仁さん(M2)が2015年日本家禽学会春季大会(宇都宮大学)で優秀発表賞を受賞
  • 寺田遥香さん(M2)が平成25年東海畜産学会(WINCあいち)で優秀発表賞を受賞
  • 瀧本拓央さん(M1)が2012年日本家禽学会春季大会(名古屋大学)優秀発表賞を受賞
  • 土井香澄さん(M1)が第114回日本畜産学会大会(北里大学)優秀発表賞を受賞
  • 北原一樹さん(M1)が第2011年回日本家禽学会秋季大会(北里大学)優秀発表賞を受賞
  • Baeさん(2009年度D3)と村井准教授の論文が2010年度Journal of Poultry ScienceのOutstanding Paper Awardを受賞
    Bae, H.-D., Honda, H., Murota, R., Kobayashi, M., Horio, F. and Murai, A.
    Production of recombinant chicken IgY-Fc and evaluation of its transport ability into avian egg yolks. J. Poult. Sci. 47:256-261 (2010)(2011年8月)
  • 三浦奈津子さん(M2)が第63回日本ビタミン学会(安田女子大)学生優秀発表賞を受賞
  • 無漏田梨恵さん(M1)が2010年日本家禽学会秋季大会(信州大学)優秀発表賞を受賞