藤本　和則 (FUJIMOTO Kazunori)

自己紹介：某製薬会社の安全性研究所に勤務しながら社会人学生として織田研究
室に所属しています。学位テーマは「創薬安全性評価に利用可能な遺伝子改変動
物の解析」で、今まで作製してきたノックアウトマウスが創薬安全性評価におい
てどういう生物学的特性の上で利用可能かを調査・解析していきたいと考えてい
ます。

所属学会：日本実験動物学会，日本トキシコロジー学会

論文：
Sonta S, Nomura N, Fujimoto K, Ono T, Kawamoto T, Aoi T (1996) Chinese
hamster stocks with X-ray-induced chromosome rearrangements and their
ferti1ity. Chrom Inform Serv 61:18-20.

Fujimoto K, Oda S, Koyasu K, Harada M, Sonta S (1997) Comparative analysis
of the karyotypes of the greater long-tailed hamster and the Chinese
hamster. Cytologia 62:315-321.

Ando Y, Takeshita S, Fujimoto K, Shimizu M, Nagata M, Kikuchi T, Wakasugi N
(2001) Genetic mapping of a neurological mutation cerebellar calcification
in the rat. Mamm Genome 12:80-82.

Fujimoto K, Koishi R, Shimizugawa T, Ando Y (2006) Angptl3-null mice show
low plasma lipid concentrations by enhanced lipoprotein lipase activity. Exp
Anim 55:27-34.

Fujimoto K, Arakawa S, Shibaya Y, Miida H, Ando Y, Yasumo H, Hara A,
Uchiyama M, Iwabuchi H, Takasaki W, Manabe S, Yamoto T (2006) Characterization of
phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies
using 1,2-dichloro-4-nitrobenzene. Drug Metab Dispos 34:1495-1501.

Shimamura M, Matsuda M, Yasumo H, Okazaki M, Fujimoto K, Kono K,
Shimizugawa T, Ando Y, Koishi R, Kohama T, Sakai N, Kotani K, Komuro R, Ishida T,
Hirata K, Yamashita S, Furukawa H, Shimomura I (2007) Angiopoietin-like
protein 3 regulates plasma HDL cholesterol through suppression of endothelial
lipase. Arterioscler Thromb Vasc Biol 27:366-372.

Fujimoto K, Arakawa S, Watanabe T, Yasumo H, Ando Y, Takasaki W, Manabe S,
Yamoto T, Oda S (2007) Generation and functional characterization of mice
with a disrupted glutathione S-transferase, theta 1 gene. Drug Metab Dispos
35:2196-2202.

Mitsutake S, Yokose U, Koto M, Matsuoka I, Yoo JM, Kim TJ, Yoo HS, Fujimoto
K, Ando Y, Sugiura M, Kohama T, Igarashi Y (2007) The generation and
behavioral analysis of ceramide kinase-null mice, indicating a function
incerebellar Purkinje cells. Biochem Biophys Res Commun 363:519-524.